SCHEMBL3280902

SCHEMBL3280902

O=C(Cl)c1cc(C(F)(F)F)nn1-c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GRN P28799 1/20 0.56
SORT1 Q99523 1/20 0.56
KLKB1 P03952 5/20 0.55
PTGS1 P23219 2/20 0.55
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
CARM1 Q86X55 6/20 0.48
KCNJ6 P48051 1/20 0.48
KCNJ5 P48544 1/20 0.48
KCNJ3 P48549 1/20 0.48
NR3C2 P08235 1/20 0.46
MAPT P10636 1/20 0.46
PTGS2 P35354 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950904 0.88 GRN (0.72) GRNSORT1KLKB1PTGS1KDM4E
SCHEMBL27584609 0.85 KLKB1 (0.61) GRNSORT1KLKB1PTGS1KDM4E
SCHEMBL6173027 0.82 PTGS2 (0.60) PTGS1PTGS2
SCHEMBL7231373 0.82 KLKB1 (0.51) KLKB1CARM1
SCHEMBL951285 0.81 RXRA (0.49) KLKB1PTGS1KDM4EALDH1A1CARM1
SCHEMBL1670472 0.81 GRN (0.56) GRNSORT1KLKB1PTGS1KDM4E
SCHEMBL12361486 0.80 KLKB1 (0.75) KLKB1CARM1MAPT
SCHEMBL5584120 0.78 KLKB1 (0.69) GRNSORT1KLKB1KDM4E
SCHEMBL12361464 0.78 ALDH1A1 (0.53) GRNSORT1KLKB1PTGS1KDM4E
SCHEMBL18604629 0.78 PTGS2 (0.58) GRNSORT1KLKB1PTGS1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9173400-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2015-11-03 US disclosed
US-9113630-B2 Method of controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2015-08-25 US disclosed
US-20140140973-A1 METHOD OF CONTROLLING PARTICULAR INSECT PESTS BY APPLYNG ANTHRANILAMIDE COMPOUNDS E I DU PONT DE NEMOURS AND COMPANY (US) 2014-05-22 US disclosed
US-20140141972-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E I DU PONT NEMOURS AND COMPANY (US) 2014-05-22 US disclosed
US-8697734-B2 Method for controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2014-04-15 US disclosed
US-8637552-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-28 US disclosed
US-20130028879-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-31 US disclosed
US-20130031677-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-31 US disclosed
US-7998995-B2 LXR and FXR modulators EXELIXIS PATENT COMPANY LLC (US) 2011-08-16 US disclosed
US-20100160307-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-06-24 US disclosed
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds E. I. DU PONT DE NEMOURS AND COMPANY 2005-04-07 US disclosed
CN-1541063-A Method for controlling particular insects by applying anthranilamide compounds ��Ļ���Ű˾ 2004-10-27 CN disclosed
US-20040209923-A1 Anthranilamide arthropodicide treatment FMC CORPORATION 2004-10-21 US disclosed
US-20040142984-A1 Insecticidal anthranilamides FMC CORPORATION 2004-07-22 US disclosed
EP-1427285-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E. I. du Pont de Nemours and Company (US) 2004-06-16 EP disclosed
US-6747047-B2 ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY 2004-06-08 US disclosed
EP-1416796-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 EP disclosed
US-20030229050-A1 Insecticidal anthranilamides FMC CORPORATION 2003-12-11 US disclosed
WO-2003024222-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E. I. DU PONT DE NEMOURS AND COMPANY (US) 2003-03-27 WO disclosed
WO-2003015518-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100160307-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS ANTXR2, HRH4, HDAC10 GRN 3481/4885SORT1 3126/4885KLKB1 3840/4885
US-20140140973-A1 METHOD OF CONTROLLING PARTICULAR INSECT PESTS BY APPLYNG ANTHRANILAMIDE COMPOUNDS ANTXR2, NIT2, TDO2 GRN 3252/4885SORT1 2640/4885KLKB1 3874/4885
US-20130031677-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT ANTXR2, ARF5, NPR1 GRN 2806/4885SORT1 1386/4885KLKB1 4489/4885
US-20040142984-A1 Insecticidal anthranilamides ANTXR2, NIT2, AKR7A2 GRN 4628/4885SORT1 4688/4885KLKB1 3650/4885
US-20040209923-A1 Anthranilamide arthropodicide treatment ANTXR2, ARF5, NPM1 GRN 2638/4885SORT1 1794/4885KLKB1 4175/4885
US-20030229050-A1 Insecticidal anthranilamides ANTXR2, NIT2, CYB5R3 GRN 4664/4885SORT1 4741/4885KLKB1 3480/4885
US-20130028879-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS ANTXR2, CYP4X1, PRDX1 GRN 4350/4885SORT1 3540/4885KLKB1 3929/4885
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds ANTXR2, HRH4, HDAC10 GRN 3403/4885SORT1 3118/4885KLKB1 3842/4885
US-20140141972-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT ANTXR2, ARF5, NPR1 GRN 2806/4885SORT1 1386/4885KLKB1 4489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.