Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852329 | 0.88 | ALDH1A1 (0.41) | ALDH1A1RAB9AKMT2AHPGDMAPT | |
| SCHEMBL328412 | 0.87 | MMP3 (0.37) | KMT2AHPGDMEN1MMP3F10 | |
| SCHEMBL6850151 | 0.85 | ALDH1A1 (0.35) | ALDH1A1RAB9AKMT2AHPGDMAPT | |
| SCHEMBL6852266 | 0.84 | HRH3 (0.36) | KMT2AADRB2 | |
| SCHEMBL6852333 | 0.84 | MMP3 (0.39) | KMT2AMEN1MMP3F10 | |
| SCHEMBL6852386 | 0.83 | MMP3 (0.38) | KMT2AMEN1MMP3F10 | |
| SCHEMBL6852594 | 0.83 | AHCY (0.44) | ALDH1A1NPSR1MMP3 | |
| SCHEMBL328480 | 0.83 | MMP3 (0.47) | ALDH1A1RAB9AMAPTPOLBMCOLN3 | |
| SCHEMBL328556 | 0.82 | MMP3 (0.40) | KMT2AMAPTMEN1MMP3F10 | |
| SCHEMBL6852303 | 0.81 | ADRB2 (0.38) | ALDH1A1KMT2AMEN1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |