Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | AHCY | P23526 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852333 | 0.99 | MMP3 (0.39) | MMP3LTA4HPTGS2F10AHCY | |
| SCHEMBL10067173 | 0.91 | MMP3 (0.49) | MMP3LTA4HPTGS2AHCYMMP9 | |
| SCHEMBL328413 | 0.90 | MMP3 (0.51) | MMP3AHCYHRH3MMP9MMP2 | |
| SCHEMBL6852594 | 0.88 | AHCY (0.44) | MMP3AHCY | |
| SCHEMBL328412 | 0.86 | MMP3 (0.37) | MMP3F10AHCYMMP9MMP2 | |
| SCHEMBL328556 | 0.85 | MMP3 (0.40) | MMP3F10AHCYHRH3MMP9 | |
| SCHEMBL328551 | 0.83 | ALDH1A1 (0.36) | MMP3F10MEN1KMT2A | |
| SCHEMBL6852592 | 0.83 | CHRM5 (0.35) | MMP9MMP2MMP1MMP13ADAM17 | |
| SCHEMBL6852266 | 0.82 | HRH3 (0.36) | HRH3MMP9MMP2MMP1MMP13 | |
| SCHEMBL328473 | 0.82 | F13A1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |