Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | AHCY | P23526 | 4/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850180 | 0.94 | MMP9 (0.40) | MMP3MMP2MMP9SOS1 | |
| SCHEMBL10066483 | 0.92 | MMP3 (0.41) | MMP3MMP2MMP9F10KEAP1 | |
| SCHEMBL6863812 | 0.91 | MMP3 (0.52) | MMP3MMP2MMP9AHCY | |
| SCHEMBL6850247 | 0.90 | ADRB2 (0.44) | KMT2AMAPTMEN1PSEN1PSEN2 | |
| SCHEMBL328544 | 0.87 | DAGLA (0.35) | KMT2AHRH3CA12CA9SOS1 | |
| SCHEMBL6852333 | 0.86 | MMP3 (0.39) | MMP3MMP2MMP9F10AHCY | |
| SCHEMBL328412 | 0.85 | MMP3 (0.37) | MMP3MMP2MMP9F10AHCY | |
| SCHEMBL6852386 | 0.85 | MMP3 (0.38) | MMP3MMP2MMP9F10AHCY | |
| SCHEMBL6852594 | 0.85 | AHCY (0.44) | MMP3AHCYCA12CA9 | |
| SCHEMBL328560 | 0.84 | MMP3 (0.44) | MMP3MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |