Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.36 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | STS | P08842 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850151 | 0.93 | ALDH1A1 (0.35) | MMP1MMP13SLC9A3ADRB2MMP2 | |
| SCHEMBL6850229 | 0.92 | ALDH1A1 (0.39) | MMP9MMP2ALDH1A1MAPT | |
| SCHEMBL6865124 | 0.92 | MMP3 (0.40) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6852266 | 0.86 | HRH3 (0.36) | MMP9MMP1MMP13ADAM17ADRB2 | |
| SCHEMBL10067177 | 0.85 | MMP3 (0.44) | MMP9MMP1MMP13MMP2KMT2A | |
| SCHEMBL6850180 | 0.84 | MMP9 (0.40) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6864658 | 0.83 | MMP3 (0.46) | MMP9MMP1MMP13MMP2ALDH1A1 | |
| SCHEMBL328661 | 0.83 | KMT2A (0.38) | KMT2AGAAALDH1A1 | |
| SCHEMBL328414 | 0.82 | DAGLA (0.37) | MMP9MMP2KMT2AALDH1A1 | |
| SCHEMBL328548 | 0.81 | DAGLA (0.37) | SLC9A3KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |