Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328556 | 0.94 | MMP3 (0.40) | MMP9MMP2SOS1MMP3 | |
| SCHEMBL10066483 | 0.92 | MMP3 (0.41) | MMP9MMP13MMP2MMP3ALDH1A1 | |
| SCHEMBL6850247 | 0.91 | ADRB2 (0.44) | ALDH1A1GAA | |
| SCHEMBL328560 | 0.91 | MMP3 (0.44) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL328544 | 0.87 | DAGLA (0.35) | SOS1ALDH1A1 | |
| SCHEMBL6852266 | 0.85 | HRH3 (0.36) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL328650 | 0.84 | MMP9 (0.36) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL6863812 | 0.84 | MMP3 (0.52) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL328555 | 0.83 | MMP3 (0.53) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL328414 | 0.83 | DAGLA (0.37) | MMP9MMP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |