Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PCNA | P12004 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850151 | 0.92 | ALDH1A1 (0.35) | ALDH1A1MAPTMMP2LMNASMN1; SMN2 | |
| SCHEMBL6864658 | 0.92 | MMP3 (0.46) | ALDH1A1MAPTMMP2MMP9LMNA | |
| SCHEMBL328650 | 0.92 | MMP9 (0.36) | ALDH1A1MAPTMMP2MMP9 | |
| SCHEMBL10066483 | 0.84 | MMP3 (0.41) | ALDH1A1MAPTMMP2MMP9SMN1; SMN2 | |
| SCHEMBL10067177 | 0.84 | MMP3 (0.44) | ALDH1A1MAPTMMP2MMP9RAB9A | |
| SCHEMBL6865124 | 0.83 | MMP3 (0.40) | MMP2MMP9MMP3BMP1 | |
| SCHEMBL328661 | 0.82 | KMT2A (0.38) | ALDH1A1RAB9APOLBL3MBTL1BMP1 | |
| SCHEMBL328488 | 0.81 | MMP3 (0.42) | ALDH1A1MAPTMMP2MMP9LMNA | |
| SCHEMBL328414 | 0.81 | DAGLA (0.37) | ALDH1A1MMP2MMP9SMN1; SMN2POLB | |
| SCHEMBL328548 | 0.80 | DAGLA (0.37) | ALDH1A1MAPTSMN1; SMN2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |