Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328646 | 0.90 | MMP13 (0.46) | MEN1KMT2AATMDAGLATDP1 | |
| SCHEMBL328658 | 0.88 | HSP90AA1 (0.41) | DAGLATDP1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL328473 | 0.85 | F13A1 (0.41) | DAGLAMAPTPGR | |
| SCHEMBL6850664 | 0.82 | DAGLA (0.43) | ATMDAGLAL3MBTL1PGR | |
| SCHEMBL328477 | 0.81 | CA1 (0.35) | KMT2ADAGLAL3MBTL1UTS2R | |
| SCHEMBL328414 | 0.81 | DAGLA (0.37) | KMT2ADAGLASMN1; SMN2L3MBTL1PGR | |
| SCHEMBL328548 | 0.81 | DAGLA (0.37) | KMT2ADAGLASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL328661 | 0.81 | KMT2A (0.38) | KMT2ADAGLATDP1L3MBTL1 | |
| SCHEMBL328478 | 0.79 | LMNA (0.35) | DAGLA | |
| SCHEMBL6850484 | 0.79 | DAGLA (0.36) | KMT2ADAGLATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |