Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863154 | 0.90 | MMP1 (0.40) | HSP90AA1KDM4EMAPTHTTMMP13 | |
| SCHEMBL328662 | 0.88 | MEN1 (0.39) | MAPTTDP1SMN1; SMN2L3MBTL1DAGLA | |
| SCHEMBL328477 | 0.83 | CA1 (0.35) | L3MBTL1DAGLAALDH1A1LMNACA12 | |
| SCHEMBL328414 | 0.83 | DAGLA (0.37) | SMN1; SMN2L3MBTL1DAGLAALDH1A1CA12 | |
| SCHEMBL328659 | 0.82 | RORC (0.40) | TDP1TBXA2RTBXAS1ALDH1A1 | |
| SCHEMBL6850664 | 0.82 | DAGLA (0.43) | MMP13L3MBTL1DAGLAALDH1A1 | |
| SCHEMBL328661 | 0.82 | KMT2A (0.38) | TDP1L3MBTL1GAADAGLAALDH1A1 | |
| SCHEMBL328548 | 0.82 | DAGLA (0.37) | MAPTSMN1; SMN2L3MBTL1DAGLAALDH1A1 | |
| SCHEMBL328473 | 0.81 | F13A1 (0.41) | MAPTDAGLALMNA | |
| SCHEMBL6850285 | 0.80 | MMP13 (0.41) | HTTMMP13TDP1TBXA2RTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |