1-Hydroxy-3-Methoxybenzene

1-Hydroxy-3-Methoxybenzene

SCHEMBL3289339

COc1cccc([O-])c1.[K+]

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA

The experimentally established mechanism targets of 1-Hydroxy-3-Methoxybenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.54
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
ALDH1A1 P00352 1/20 0.52
CYP3A4 P08684 1/20 0.52
ENPP2 Q13822 1/20 0.52
CES2 O00748 1/20 0.47
CES1 P23141 1/20 0.47
CA4 P22748 1/20 0.46
CHRM5 P08912 1/20 0.45
IDO1 P14902 2/20 0.44
AGXT P21549 2/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
PARP1 P09874 1/20 0.44
RELA Q04206 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
DYRK1A Q13627 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Hydroxy-3-Methoxybenzene SCHEMBL31616066 0.95 ACHE (0.54) ACHECA1CA2CA7CA9
1-Hydroxy-3-Methoxybenzene SCHEMBL6064728 0.95 ACHE (0.54) ACHECA1CA2CA7CA9
1-Hydroxy-3-Methoxybenzene SCHEMBL6904887 0.95 ACHE (0.54) ACHECA1CA2CA7CA9
1-Hydroxy-3-Methoxybenzene SCHEMBL3288076 0.95 ACHE (0.54) ACHECA1CA2CA7CA9
1-Hydroxy-3-Methoxybenzene SCHEMBL8168667 0.95 ACHE (0.54) ACHECA1CA2CA7CA9
1-Hydroxy-3-Methoxybenzene SCHEMBL3287924 0.95 ACHE (0.54) ACHECA1CA2CA7CA9
1,3-Dimethoxybenzene SCHEMBL9350 0.79 ACHE (0.70) ACHECA1CA2CA7CA9
1,3-Dimethoxybenzene SCHEMBL901285 0.79 ACHE (0.70) ACHECA1CA2CA7CA9
1-Hydroxy-3-Methoxybenzene SCHEMBL7085847 0.78 KCNH2 (0.49) ACHECA1CA2CA7CA9
1-Hydroxy-3-Methoxybenzene SCHEMBL7085846 0.77 CES2 (0.41) ACHECA1CA2CA9ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9587060-B2 Functionalized rubbery polymers THE GOODYEAR TIRE & RUBBER COMPANY (US) 2017-03-07 US disclosed
US-7714089-B2 Functionalized monomers and functionalized rubbery polymers made therewith THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-05-11 US disclosed
US-20090156769-A1 FUNCTIONALIZED MONOMERS AND FUNCTIONALIZED RUBBERY POLYMERS MADE THEREWITH THE GOODYEAR TIRE & RUBBER COMPANY 2009-06-18 US disclosed
US-7291687-B1 Catalyst system for synthesizing rubbery polymers having a high trans microstructure content THE GOODYEAR TIRE AND RUBBER COMPANY (US) 2007-11-06 US disclosed
EP-1792892-A2 Functionalized rubbery polymers THE GOODYEAR TIRE & RUBBER COMPANY (US) 2007-06-06 EP disclosed
US-20070123631-A1 Functionalized rubbery polymers THE GOODYEAR TIRE & RUBBER COMPANY 2007-05-31 US disclosed
US-7222650-B2 Tire with a tread comprising a rubbery polymer of a functionalized monomer THE GOODYEAR TIRE & RUBBER COMPANY (US) 2007-05-29 US disclosed
US-6995224-B2 Functionalized monomers for synthesis of rubbery polymers THE GOODYEAR TIRE & RUBBER COMPANY (US) 2006-02-07 US disclosed
US-6936669-B2 Functionalized monomers for synthesis of rubbery polymers THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-08-30 US disclosed
US-6933358-B2 Reacting secordary amine with 2,3-dihalopropene forming monomer THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-08-23 US disclosed
US-4110421-A Catalytic process for the preparation of phosphazene polymers ARMSTRONG CORK COMPANY (US) 1978-08-29 US disclosed
US-4108805-A FIRE RETARDANT ARMSTRONG CORK COMPANY (US) 1978-08-22 US disclosed
US-4107108-A FOAMED FIRE-RETARDANT ARMSTRONG CORK COMPANY (US) 1978-08-15 US disclosed
US-4076658-A BLOWING AGENT ARMSTRONG CORK COMPANY (US) 1978-02-28 US disclosed
US-4073824-A FIRE RETARDANT, NONSMOKING ARMSTRONG CORK COMPANY (US) 1978-02-14 US disclosed
US-4055520-A FIRE RETARDANT ARMSTRONG CORK COMPANY (US) 1977-10-25 US disclosed
US-4055545-A SOLID CARBOXYLIC ACID ARMSTRONG CORK COMPANY (US) 1977-10-25 US disclosed
US-4055523-A FIRE RETARDANT ARMSTRONG CORK COMPANY (US) 1977-10-25 US disclosed
US-4053456-A CROSSLINKING, SMOKELESS ARMSTRONG CORK COMPANY (US) 1977-10-11 US disclosed
US-4026838-A INCORPORATING A SOLID CARBOXYLIC ACID ARMSTRONG CORK COMPANY (US) 1977-05-31 US disclosed