SCHEMBL3300842

SCHEMBL3300842

Fc1cc(C(F)(F)F)cc(Cl)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
CYP3A4 P08684 2/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
HIF1A Q16665 1/20 0.41
TXNRD1 Q16881 1/20 0.41
TXNRD3 Q86VQ6 1/20 0.41
TXNRD2 Q9NNW7 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
HSD11B1 P28845 1/20 0.37
PDE2A O00408 2/20 0.37
GPR35 Q9HC97 2/20 0.36
GAA P10253 1/20 0.36
HTT P42858 1/20 0.36
GABRA2 P47869 3/20 0.36
GABRB2 P47870 3/20 0.36
GABRB3 P28472 3/20 0.36
GABRP O00591 2/20 0.36
GABRD O14764 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7922004 0.87 ALDH1A1 (0.45) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL981089 0.85 ALDH1A1 (0.46) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL1531168 0.81 PDE2A (0.37) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL24610569 0.79 GABRB2 (0.36) ALDH1A1CYP3A4HSD11B1GAAGABRA2
SCHEMBL13550139 0.79 RAPGEF4 (0.43) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL9088284 0.77 ALDH1A1 (0.38) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL8773859 0.77 PDE2A (0.39) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL15958860 0.77 PDE2A (0.43) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL31513958 0.77 GABRB3 (0.39) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL2790205 0.77 CA1 (0.46) ALDH1A1CYP3A4HPGDALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes BASF SE (DE) 2010-04-22 US claimed
EP-2137135-A1 PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES BASF SE (DE) 2009-12-30 EP claimed
WO-2008113660-A1 PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES BASF SE (DE) 2008-09-25 WO claimed
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes BASF SE (DE) 2010-04-22 US disclosed
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes BASF SE (DE) 2010-04-22 US disclosed
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes BASF SE (DE) 2010-04-22 US disclosed
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes BASF SE (DE) 2010-04-22 US disclosed
CN-101631767-A Process for preparing 2,6-dichloro-4-(trifluoromethyl)phenylhydrazine using mixtures of dichloro-fluoro-trifluoromethylbenzenes BASF SE 2010-01-20 CN disclosed
EP-2137135-A1 PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES BASF SE (DE) 2009-12-30 EP disclosed
WO-2008113660-A1 PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES BASF SE (DE) 2008-09-25 WO disclosed
WO-2008113660-A1 PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES BASF SE (DE) 2008-09-25 WO disclosed
EP-0379915-A1 Substituted phenoxybenzonitrile derivatives, processes for their preparation and their use as herbicides and plant growth regulators BAYER AG (DE) 1990-08-01 EP disclosed
EP-0369212-A1 Derivatives of (hetero)aryloxynaphthalene, process, and (hetero)aryloxynaphthyl amines, and their use as herbicides BAYER AG (DE) 1990-05-23 EP disclosed
EP-0361067-A1 Disubstituted naphthalines, preparation processes and their herbicidal use BAYER AG (DE) 1990-04-04 EP disclosed
EP-0354329-A1 (Hetero) aryloxynaphthalenes with substituents linked over sulphur BAYER AG (DE) 1990-02-14 EP disclosed
EP-0347679-A1 1,7-Dioxynaphthalene derivatives BAYER AG (DE) 1989-12-27 EP disclosed
EP-0315008-A2 Derivatives of (6-(hetero)aryloxy-naphthalin-2-yl-oxy)alcanoic acid BAYER AG (DE) 1989-05-10 EP disclosed
EP-0313908-A2 Halogen-substituted phenoxyphenylpropionic acid derivatives BAYER AG (DE) 1989-05-03 EP disclosed
EP-0309864-A1 Alpha-(5-aryloxy-naphthalen-1-yl-oxy)-propionic-acid derivatives BAYER AG (DE) 1989-04-05 EP disclosed
EP-0308755-A2 Derivatives of 7-(hetero)aryloxy-naphthalen-2-yloxy)alcanoic acid BAYER AG (DE) 1989-03-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes DAZAP1, CYP4Z1, CYP2F1 ALDH1A1 93/4885CYP3A4 41/4885HPGD 523/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.