SCHEMBL7922004

SCHEMBL7922004

Fc1cc(C(F)(F)F)cc(F)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
TSHR P16473 2/20 0.45
CYP3A4 P08684 1/20 0.45
HPGD P15428 1/20 0.45
ALOX15 P16050 1/20 0.45
HIF1A Q16665 1/20 0.45
TXNRD1 Q16881 1/20 0.45
TXNRD3 Q86VQ6 1/20 0.45
TXNRD2 Q9NNW7 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
GPR35 Q9HC97 2/20 0.39
CES2 O00748 1/20 0.37
HSD11B1 P28845 1/20 0.37
PDE2A O00408 3/20 0.36
IDO1 P14902 2/20 0.35
GABRA2 P47869 2/20 0.35
GABRB2 P47870 2/20 0.35
TLR7 Q9NYK1 1/20 0.35
GABRP O00591 1/20 0.35
GABRD O14764 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3300842 0.87 ALDH1A1 (0.41) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL13550139 0.85 RAPGEF4 (0.43) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL1531168 0.77 PDE2A (0.37) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL27581177 0.77 GPR35 (0.41) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL2005442 0.77 CES2 (0.40) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL20303548 0.76 PDE2A (0.53) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL24610554 0.76 GABRB2 (0.40) ALDH1A1TSHRHPGDALOX15TDP1
SCHEMBL3944248 0.76 ALOX15 (0.36) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL15850519 0.74 CES2 (0.39) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL981089 0.74 ALDH1A1 (0.46) ALDH1A1TSHRCYP3A4HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140735-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2001-10-10 EP disclosed
WO-2000040524-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2000-07-13 WO disclosed
US-5981789-A CHLORODENITRATING AROMATIC COMPOUNDS USING LESS CHLORINATING AGENT AND LOWER TEMPERATURES, THEN RECYCLING THE PRODUCT MIXTURE TO INCREASE THE YIELD OCCIDENTAL CHEMICAL CORPORATION (US) 1999-11-09 US disclosed
US-4952719-A Process for the preparation of halo aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1990-08-28 US disclosed
EP-0180057-B1 PROCESS FOR THE PREPARATION OF HALO AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 1989-08-09 EP disclosed
EP-0289036-A1 Preparation of 3-chloro-4,5-difluorobenzotrifluoride OCCIDENTAL CHEMICAL CORPORATION (US) 1988-11-02 EP disclosed
US-4704483-A FLUORINATION WITH POTASSIUM FLUORIDE OCCIDENTAL CHEMICAL CORPORATION (US) 1987-11-03 US disclosed
US-4603222-A Method for the preparation of nitrodiphenyl ethers OCCIDENTAL CHEMICAL CORPORATION (US) 1986-07-29 US disclosed
US-4590315-A Process for the preparation of halo aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1986-05-20 US disclosed
EP-0180057-A1 Process for the preparation of halo aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1986-05-07 EP disclosed
US-4582948-A VAPOR PHASE CHLORO-DENITRATION REACTION OCCIDENTAL CHEMICAL CORPORATION (US) 1986-04-15 US disclosed
EP-0173349-A1 Method for the preparation of nitrodiphenyl ethers OCCIDENTAL CHEMICAL CORPORATION (US) 1986-03-05 EP disclosed
EP-0159388-A2 Preparation of nuclear chlorinated compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1985-10-30 EP disclosed