Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2236507 | 0.83 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL7896750 | 0.83 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL4396839 | 0.81 | L3MBTL1 (0.63) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL16712195 | 0.81 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDPOLBKMT2A | |
| SCHEMBL6113219 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL28417626 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL6050314 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL4396834 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL30266645 | 0.79 | PDIA6 (0.55) | ALDH1A1MAPTHPGDPOLBALOX12 | |
| SCHEMBL11587898 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDPOLBALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547952-A | TREATMENT OF CATARACTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-08-20 | — | — | US | claimed |
| US-20180258038-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-09-13 | — | — | US | disclosed |
| US-10000450-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-06-19 | — | — | US | disclosed |
| US-20170166524-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-06-15 | — | — | US | disclosed |
| US-9611214-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-04 | — | — | US | disclosed |
| CN-103613527-B | N, N-substituted 3-aminopyrrolidine compounds useful as monoamine reuptake inhibitors | OTSUKA PHARMACEUTICAL CO.,LTD. (JP) | 2016-02-24 | — | — | CN | disclosed |
| EP-2489706-B1 | Ink composition and ink jet recording method using the same | SEIKO EPSON CORP (JP) | 2015-03-04 | — | — | EP | disclosed |
| US-20140288065-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-09-25 | — | — | US | disclosed |
| US-8815871-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| CN-103108924-B | Ink composition, inkjet recording method and colored body | NIPPON KAYAKU KK | 2014-08-20 | — | — | CN | disclosed |
| US-7087778-B2 | Process for producing benzoxazine derivative and production intermediate thereof | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-08-08 | — | — | US | disclosed |
| CN-1733744-A | Process for producing benzoxazine derivative and production intermediate thereof | DAIICHI SEIYAKU CO (JP) | 2006-02-15 | — | — | CN | disclosed |
| US-20060014947-A1 | Process for producing benzoxazine derivative and production intermediate thereof | DAIICHI PHARMACEUTICAL CO., LTD. | 2006-01-19 | — | — | US | disclosed |
| WO-2005092832-A1 | METHOD OF PRODUCING AMINOPHENOL COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-10-06 | — | — | WO | disclosed |
| CN-1195759-C | Process for preparing benzoxazine derivatives and intermediates thereof | DAIICHI SEIYAKU CO (JP) | 2005-04-06 | — | — | CN | disclosed |
| US-6872823-B1 | Process for producing benzoxazine derivative and production intermediate thereof | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| US-20050027119-A1 | Process for producing benzoxazine derivative and production intermediate thereof | DAIICHI PHARMACEUTICAL CO., LTD. | 2005-02-03 | — | — | US | disclosed |
| CN-1532181-A | Intermediate for preparing benzoxazine derivative and preparation method thereof | 第一制药株式会社 | 2004-09-29 | — | — | CN | disclosed |
| CN-1379779-A | Process for preparing benzoxazine derivatives and intermediates thereof | DAIICHI SEIYAKU CO (JP) | 2002-11-13 | — | — | CN | disclosed |
| EP-1211254-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZINE DERIVATIVES AND INTERMEDIATES THEREFOR | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2002-06-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000450-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885MAPT 1263/4885HPGD 1739/4885 |
| US-20060014947-A1 | Process for producing benzoxazine derivative and production intermediate thereof | CYP4Z1, COASY, VAT1 | ALDH1A1 393/4885MAPT 3583/4885HPGD 141/4885 |
| US-20180258038-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885MAPT 1263/4885HPGD 1739/4885 |
| US-20170166524-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885MAPT 1263/4885HPGD 1739/4885 |
| US-20050027119-A1 | Process for producing benzoxazine derivative and production intermediate thereof | CYP4Z1, COASY, VAT1 | ALDH1A1 299/4885MAPT 3516/4885HPGD 134/4885 |
| US-20140288065-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885MAPT 1263/4885HPGD 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.