Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13226423 | 0.80 | ALOX5 (0.48) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL25332706 | 0.79 | KDM4E (0.55) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL23879789 | 0.78 | MMP3 (0.56) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL289813 | 0.76 | KDM4E (0.52) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL13395921 | 0.75 | MMP3 (0.56) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL13947098 | 0.75 | KDM4E (0.50) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL353101 | 0.75 | KDM4E (0.62) | KDM4EALDH1A1MAPTTHRBGAA | |
| SCHEMBL23879802 | 0.74 | KDM4E (0.50) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL23879785 | 0.74 | KDM4E (0.50) | MMP3MMP1MMP7MMP9MMP8 | |
| SCHEMBL9510452 | 0.74 | KDM4E (0.38) | KDM4EALDH1A1MAPTTHRBHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889556-B2 | Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-01-12 | — | — | US | disclosed |
| US-20190106398-A1 | COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-11 | — | — | US | disclosed |
| WO-2017156194-A1 | COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-09-14 | — | — | WO | disclosed |
| US-7786316-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-08-31 | — | — | US | disclosed |
| US-20100098640-A1 | Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2010-04-22 | — | — | US | disclosed |
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD TECHNOLOGY TRANSFER OFFICE (US) | 2009-11-19 | — | — | US | disclosed |
| US-7579486-B2 | Metalloprotein inhibitors | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2009-08-25 | — | — | US | disclosed |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO | 2007-05-24 | — | — | US | disclosed |
| WO-2007002109-A2 | MULTIDENTATE PYRONE-DERIVED CHELATORS FOR MEDICINAL IMAGING AND CHELATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106398-A1 | COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE | POLRMT, RNASE1, POLM | MMP3 161/4885MMP1 89/4885MMP7 275/4885 |
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | MMP3 50/4885MMP1 9/4885MMP7 26/4885 |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | MMP3 50/4885MMP1 9/4885MMP7 26/4885 |
| US-10889556-B2 | Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease | POLRMT, RNASE1, POLM | MMP3 161/4885MMP1 89/4885MMP7 275/4885 |
| US-20100098640-A1 | Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation | DNM1, BET1, FOLH1 | MMP3 1798/4885MMP1 1596/4885MMP7 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.