SCHEMBL3311060

SCHEMBL3311060

Clc1cc(CBr)c(CBr)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AHR P35869 5/20 0.35
MAPK1 P28482 1/20 0.35
FLT1 P17948 1/20 0.33
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TP53 P04637 1/20 0.32
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
IDO1 P14902 1/20 0.31
CYP3A4 P08684 1/20 0.30
PNMT P11086 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29472350 1.00 AHR (0.35) AHRMAPK1FLT1HPGDTSHR
SCHEMBL9396186 0.88 MAPK1 (0.38) AHRMAPK1FLT1HPGDTSHR
SCHEMBL9292254 0.87 ALOX15 (0.36) MAPK1ALOX15ALOX12IDO1CYP3A4
SCHEMBL3875287 0.81 GPR84 (0.38) CYP3A4
SCHEMBL12659938 0.81 CD44 (0.42) HSD17B10ALOX15ALOX12CYP3A4
SCHEMBL23214736 0.81 HSD17B10 (0.48) MAPK1HPGDTSHRHSD17B10ALOX15
SCHEMBL338590 0.78 TRPA1 (0.32) TSHR
SCHEMBL383208 0.75 TAAR1 (0.53) MAPK1TSHRCYP3A4
SCHEMBL6943976 0.75 TRPV4 (0.36) MAPK1
SCHEMBL23214719 0.75 TAAR1 (0.48) TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4527868-A2 COMPOUND AND POLYMERIC COMPOUND INCLUDING SAID COMPOUND Japan Science and Technology Agency (JP) 2025-03-26 EP disclosed
US-20250092020-A1 IDO/TDO Inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-03-20 US disclosed
US-12208110-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2025-01-28 US disclosed
US-12209079-B2 IDO/TDO inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-01-28 US disclosed
US-12145938-B2 Compound and polymer compound containing the compound JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2024-11-19 US disclosed
US-20240217976-A2 COMPOUND AND POLYMER COMPOUND CONTAINING THE COMPOUND JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2024-07-04 US disclosed
US-20240217976-A2 COMPOUND AND POLYMER COMPOUND CONTAINING THE COMPOUND JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2024-07-04 US disclosed
US-20240217976-A2 COMPOUND AND POLYMER COMPOUND CONTAINING THE COMPOUND JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2024-07-04 US disclosed
US-11963967-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2024-04-23 US disclosed
US-11919839-B2 Alpha-cinnamide compounds and compositions as HDAC8 inhibitors VALO HEALTH, INC. (US) 2024-03-05 US disclosed
US-20100113462-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2010-05-06 US disclosed
EP-2155711-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS Sanofi-Aventis (FR) 2010-02-24 EP disclosed
WO-2008151211-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2008-12-11 WO disclosed
WO-2008151211-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2008-12-11 WO disclosed
EP-0634401-B1 MDR reversal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5639887-A MULTIDRUG RESISTANT CELLS; INCREASE CELL SENSITIVITY TO ANTICANCER AGENTS AMERICAN CYANAMID COMPANY (US) 1997-06-17 US disclosed
US-5561141-A POTENTIATE ACTIVITY OF ANTITUMOR AGENTS AMERICAN CYANAMID COMPANY (US) 1996-10-01 US disclosed
US-5550149-A SULFUR-CONTAINING COMPOUNDS THAT ARE EFFECTIVE IN POTENTIATING THE ACTIVITY OF CHEMOTHERAPEUTIC ANTI-CANCER AGENTS BY INCREASING SENSITIVITY OF MULTI-DRUG RESISTANT CELLS AMERICAN CYANAMID COMPANY (US) 1996-08-27 US disclosed
US-5387685-A MDR reversal agents AMERICAN CYANAMID COMPANY 1995-02-07 US disclosed
EP-0634401-A1 MDR reversal agents AMERICAN CYANAMID COMPANY (US) 1995-01-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209079-B2 IDO/TDO inhibitor IDO1, IDO2, TDO2 AHR 44/4885MAPK1 1048/4885FLT1 1891/4885
US-20240217976-A2 COMPOUND AND POLYMER COMPOUND CONTAINING THE COMPOUND RAD51, MDM2, UBE2D3 AHR 955/4885MAPK1 3098/4885FLT1 368/4885
US-12208110-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS1, SGMS2 AHR 4323/4885MAPK1 2927/4885FLT1 3829/4885
US-12145938-B2 Compound and polymer compound containing the compound RAD51, MDM2, UBE2D3 AHR 955/4885MAPK1 3098/4885FLT1 368/4885
US-11963967-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS2, SGMS1 AHR 3531/4885MAPK1 4211/4885FLT1 4836/4885
US-20250092020-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 AHR 44/4885MAPK1 1048/4885FLT1 1891/4885
US-11919839-B2 Alpha-cinnamide compounds and compositions as HDAC8 inhibitors HDAC8, HDAC7, HDAC1 AHR 1857/4885MAPK1 2579/4885FLT1 4632/4885
US-20100113462-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS CXCR5, CXCR1, CCR5 AHR 1016/4885MAPK1 1056/4885FLT1 1096/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.