SCHEMBL3312697

SCHEMBL3312697

C=C(CCC(=O)OC)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.62
LMNA P02545 4/20 0.45
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 3/20 0.43
HSD17B10 Q99714 3/20 0.43
KMT2A Q03164 2/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43
MEN1 O00255 1/20 0.41
CA12 O43570 1/20 0.40
CA14 Q9ULX7 1/20 0.40
MGAM O43451 1/20 0.39
GAA P10253 1/20 0.39
SI P14410 1/20 0.39
MGAM2 Q2M2H8 1/20 0.39
ALOX15 P16050 1/20 0.37
SLC1A1 P43005 1/20 0.36
TET2 Q6N021 1/20 0.35
RECQL P46063 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8417073 0.88 ALDH1A1 (0.56) TSHRLMNAKDM4EALDH1A1HSD17B10
SCHEMBL9701218 0.81 ALOX15 (0.37) TSHRALDH1A1HSD17B10ALOX15TET2
SCHEMBL4494873 0.81 TSHR (0.62) TSHRLMNAKDM4EALDH1A1HSD17B10
SCHEMBL19503488 0.80
SCHEMBL60441 0.80 MGAM (0.48) TSHRLMNAKDM4EALDH1A1HSD17B10
Dimethyl Succinate SCHEMBL28185979 0.79 TSHR (0.87) TSHRLMNAKDM4EALDH1A1HSD17B10
Dimethyl Succinate SCHEMBL28054469 0.79 TSHR (1.00) TSHRLMNAKDM4EALDH1A1HSD17B10
Dimethyl Succinate SCHEMBL10213 0.79 TSHR (1.00) TSHRLMNAKDM4EALDH1A1HSD17B10
SCHEMBL273086 0.79 TET2 (0.46) TSHRLMNAALDH1A1HSD17B10MAPT
SCHEMBL11694985 0.78 MGAM (0.46) TSHRLMNAKDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0833870-B1 POLYMERS FOR ANTIFOULING COATINGS AND A PROCESS FOR THE PREPARATION THEREOF JOTUN AS (NO) 1999-09-08 EP claimed
EP-0841380-B1 Method of making polymeric binders and use thereof in antifouling paints WITCO GMBH (DE) 1999-08-25 EP claimed
EP-0841380-A1 Method of making polymeric binders and use thereof in antifouling paints Witco GmbH (DE) 1998-05-13 EP claimed
US-3936403-A Synthetic resin composition SHOWA DENKO KABUSHIKI KAISHA (JA) 1976-02-03 US claimed
US-11639350-B2 Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections JANSSEN PHARMACEUTICA NV (BE) 2023-05-02 US disclosed
US-11459315-B2 Modulators of methyl modifying enzymes, compositions and uses thereof CONSTELLATION PHARMACEUTICALS, INC. (US) 2022-10-04 US disclosed
US-20210230148-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. 2021-07-29 US disclosed
US-20200172532-A1 HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS JANSSEN PHARMACEUTICA NV (BE) 2020-06-04 US disclosed
US-20130049264-A1 PROCESS FOR PRODUCING FLEXOGRAPHIC PRINTING PLATE PRECURSOR FOR LASER ENGRAVING, FLEXOGRAPHIC PRINTING PLATE PRECURSOR FOR LASER ENGRAVING AND PROCESS FOR MAKING FLEXOGRAPHIC PRINTING PLATE FUJIFILM CORPORATION (JP) 2013-02-28 US disclosed
US-20120210894-A1 RELIEF PRINTING PLATE PRECURSOR FOR LASER ENGRAVING AND PROCESS FOR PRODUCING SAME, AND RELIEF PRINTING PLATE AND PROCESS FOR MAKING SAME FUJIFILM CORPORATION (JP) 2012-08-23 US disclosed
US-7846963-B2 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2010-12-07 US disclosed
US-20100286207-A1 Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2010-11-11 US disclosed
US-4335254-A Polymerizable acryloyloxyarylenesulfonamides EASTMAN KODAK COMPANY (US) 1982-06-15 US disclosed
US-4289865-A USEFUL IN RELIEF IMAGES OR AS BINDERS IN PHOTOGRAPHIC MATERIALS EASTMAN KODAK COMPANY (US) 1981-09-15 US disclosed
US-4259469-A DESIRABLE SOLUBILITY CHARACTERISTICS FOR USE IN PHOTOLITHOGRAPHY EASTMAN KODAK COMPANY (US) 1981-03-31 US disclosed
US-4239848-A CONTAINING AMINES WHICH REACT WITH CARBONYL GROUPS TO CROSSLINK POLYMER EASTMAN KODAK COMPANY (US) 1980-12-16 US disclosed
US-4133687-A Photographic elements having hydrophilic colloid layers containing compounds having activator precursors and hydrophobic developing agents uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1979-01-09 US disclosed
US-4082551-A GOOD ADHESION AND BLOCKING POSITIVE CHARGED PARTICLES EASTMAN KODAK COMPANY (US) 1978-04-04 US disclosed
US-3956212-A ALUMINA TRIHYDRATE, MOLDING MATERIALS SHOWA DENKO KABUSHIKI KAISHA (JA) 1976-05-11 US disclosed
US-3936403-A Synthetic resin composition SHOWA DENKO KABUSHIKI KAISHA (JA) 1976-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286207-A1 Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same NOD2, BMP2, NOD1 TSHR 3661/4885LMNA 574/4885KDM4E 3563/4885
US-11459315-B2 Modulators of methyl modifying enzymes, compositions and uses thereof TPMT, TET1, TET2 TSHR 4512/4885LMNA 3290/4885KDM4E 93/4885
US-20200172532-A1 HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS HAVCR2, HCCS, PYGL TSHR 4103/4885LMNA 3136/4885KDM4E 4001/4885
US-11639350-B2 Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections HCCS, HAVCR2, NR1H4 TSHR 3525/4885LMNA 2714/4885KDM4E 4181/4885
US-20210230148-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF TPMT, TET1, TET2 TSHR 4512/4885LMNA 3290/4885KDM4E 93/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.