Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3312128 | 1.00 | NPSR1 (0.35) | NPSR1HCRTR1HCRTR2ALDH1A1TSHR | |
| SCHEMBL3312135 | 1.00 | NPSR1 (0.35) | NPSR1HCRTR1HCRTR2ALDH1A1TSHR | |
| SCHEMBL22688968 | 0.73 | OPRM1 (0.38) | NPSR1ALDH1A1 | |
| SCHEMBL29150660 | 0.73 | CD44 (0.36) | — | |
| SCHEMBL21619228 | 0.72 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL5527373 | 0.72 | OPRD1 (0.46) | — | |
| SCHEMBL20162423 | 0.71 | PIM1 (0.42) | — | |
| SCHEMBL17007539 | 0.71 | SMN1; SMN2 (0.43) | ALDH1A1TSHR | |
| SCHEMBL17007540 | 0.71 | LMNA (0.40) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL475036 | 0.70 | HCRTR1 (0.32) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356105-B1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | MSD OSS BV (NL) | 2013-04-10 | — | — | EP | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | CNR1, CNR2, TRPV1 | NPSR1 74/4885HCRTR1 227/4885HCRTR2 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.