SCHEMBL331479

SCHEMBL331479

CC(C)[Si](c1cccs1)(C(C)C)C(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
HPGD P15428 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CYP1A2 P05177 1/20 0.32
GAA P10253 1/20 0.32
KDM4E B2RXH2 2/20 0.32
MAPT P10636 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
FBP1 P09467 1/20 0.32
ALOX5 P09917 1/20 0.32
SLC6A3 Q01959 1/20 0.32
HTT P42858 1/20 0.31
CES2 O00748 1/20 0.30
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19875057 0.74 RPS6KB2 (0.32) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL19875003 0.74 RPS6KB2 (0.32) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL2290788 0.72 FBP1 (0.36) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL20550992 0.72 FBP1 (0.36) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL2341397 0.72
SCHEMBL8912674 0.71 FBP1 (0.39) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL29266739 0.70 MEN1 (0.38) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL19874981 0.70 DPP4 (0.33) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL8983864 0.68
SCHEMBL9190818 0.68 ALDH1A1 (0.33) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119751269-A Synthesis technology for preparing alpha-deuterated amine compound 郑州大学 2025-04-04 CN claimed
CN-119490396-A Synthetic technology for preparing deuterated aldehyde compound 郑州大学 2025-02-21 CN claimed
US-20150112028-A1 SYNTHESIS OF CHALOGEN-CAPPED PI-CONJUGATED POLYMERS UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) 2015-04-23 US claimed
CN-118344244-A Preparation method of deuterated compound based on alkyl alcohol 大连理工大学 2024-07-16 CN disclosed
EP-3416956-B1 METHYLAMINE DERIVATIVES AS LYSYL OXIDASE INHIBITORS FOR THE TREATMENT OF CANCER THE INSTITUTE OF CANCER RES ROYAL CANCER HOSPITAL (GB) 2024-04-10 EP disclosed
EP-4267567-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS Galecto Biotech AB (DK) 2023-11-01 EP disclosed
EP-4240869-A1 METHODS FOR DETECTION OF NUCLEOTIDE MODIFICATION Bluecat IP Limited (GB) 2023-09-13 EP disclosed
US-11608330-B2 Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2023-03-21 US disclosed
US-20230014870-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS GALECTO BIOTECH AB (DK) 2023-01-19 US disclosed
WO-2022136307-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS GALECTO BIOTECH AB (DK) 2022-06-30 WO disclosed
CN-114555620-A Novel galactoside inhibitors of galectins 格莱克特生物技术公司 2022-05-27 CN disclosed
WO-2002083694-A1 SYNTHESIS OF SILYL CAMPTOTHECINS AND SILYL HOMOCAMPTOTHECINS UNIVERSITY OF PITTSBURGH (US) 2002-10-24 WO disclosed
EP-1214296-A1 SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY AstraZeneca AB (SE) 2002-06-19 EP disclosed
US-6372906-B1 REACTING CAMPTOTHECIN OR HOMOCAMPTOTHECIN WITH SILYL RADICAL PRECURSOR UNDER CONDITIONS TO GENERATE SILYL RADICAL UNIVERSITY OF PITTSBURGH 2002-04-16 US disclosed
EP-1165505-A1 CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS ABBOTT LABORATORIES (US) 2002-01-02 EP disclosed
EP-1140814-A2 CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS ABBOTT LABORATORIES (US) 2001-10-10 EP disclosed
CN-1303281-A Application of compound in enhancing activity of pyruvate dehydrogenase ASTRA ZENECA LTD (SE) 2001-07-11 CN disclosed
WO-2001017956-A1 SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY ASTRAZENECA AB (SE) 2001-03-15 WO disclosed
WO-2000059880-A1 CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS ABBOTT LABORATORIES (US) 2000-10-12 WO disclosed
WO-2000039081-A2 CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS ABBOTT LABORATORIES (US) 2000-07-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230014870-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS LGALS1, LGALS3, LGALS2 ALDH1A1 979/4885HPGD 2942/4885SMN1; SMN2 4741/4885
US-11608330-B2 Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer LOXL1, LOXL3, LOXL2 ALDH1A1 2293/4885HPGD 1373/4885SMN1; SMN2 3688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.