Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3680416 | 0.82 | — | — | |
| Methacrylic Acid SCHEMBL28943430 | 0.81 | ALDH1A1 (0.35) | TSHRCHRM1AKR1A1CHRM3HTR2A | |
| Methacrylic Acid SCHEMBL25265020 | 0.77 | — | — | |
| SCHEMBL396935 | 0.75 | THRB (0.42) | TSHRTDP1 | |
| Methacrylic Acid SCHEMBL2125330 | 0.74 | USP2 (0.38) | — | |
| SCHEMBL12095175 | 0.73 | — | — | |
| SCHEMBL30969095 | 0.72 | — | — | |
| SCHEMBL393526 | 0.71 | TSHR (0.43) | TSHR | |
| Methacrylic Acid SCHEMBL27661116 | 0.69 | — | — | |
| Methacrylic Acid SCHEMBL15821451 | 0.66 | CHRM1 (0.41) | TSHRCHRM1AKR1A1CHRM3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097565-B2 | Silicone hydrogels having consistent concentrations of multi-functional polysiloxanes | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2012-01-17 | — | — | US | claimed |
| EP-1641863-A2 | SILICONE HYDROGELS HAVING CONSISTENT CONCENTRATIONS OF MULTI-FUNCTIONAL POLYSILOXANES | Johnson & Johnson Vision Care, Inc. (US) | 2006-04-05 | — | — | EP | claimed |
| US-20050255231-A1 | Silicone hydrogels having consistent concentrations of multi-functional polysiloxanes | JOHNSON & JOHNSON VISION CARE, INC. | 2005-11-17 | — | — | US | claimed |
| WO-2005005517-A2 | SILICONE HYDROGELS HAVING CONSISTENT CONCENTRATIONS OF MULTI-FUNCTIONAL POLYSILOXANES | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| US-8097565-B2 | Silicone hydrogels having consistent concentrations of multi-functional polysiloxanes | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-1641863-A2 | SILICONE HYDROGELS HAVING CONSISTENT CONCENTRATIONS OF MULTI-FUNCTIONAL POLYSILOXANES | Johnson & Johnson Vision Care, Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| US-20050255231-A1 | Silicone hydrogels having consistent concentrations of multi-functional polysiloxanes | JOHNSON & JOHNSON VISION CARE, INC. | 2005-11-17 | — | — | US | disclosed |
| WO-2005005517-A2 | SILICONE HYDROGELS HAVING CONSISTENT CONCENTRATIONS OF MULTI-FUNCTIONAL POLYSILOXANES | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050255231-A1 | Silicone hydrogels having consistent concentrations of multi-functional polysiloxanes | MMS19, FHIT, CAD | TSHR 4175/4885CHRM1 3711/4885AKR1A1 4254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.