Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trifluoroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19856417 | 0.97 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1CA5ACA5BTSHR | |
| Trifluoroacetic Acid SCHEMBL529369 | 0.91 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1CA5ACA5BTSHR | |
| Trifluoroacetic Acid SCHEMBL10510205 | 0.90 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1CA5ACA5BTSHR | |
| Trifluoromethanesulfonic Acid SCHEMBL991785 | 0.87 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1TSHRTDP1THRB | |
| Trifluoroacetic Acid SCHEMBL144167 | 0.87 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1CA5ACA5BTSHR | |
| Trifluoroacetic Acid SCHEMBL2173045 | 0.87 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1TSHRTDP1THRB | |
| Trifluoroacetic Acid SCHEMBL2484766 | 0.84 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1TSHRTHRBCA2 | |
| Trifluoroacetic Acid SCHEMBL474 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL4598430 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL7814389 | 0.84 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1TSHRTHRBCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924066-A | Trifluoroacetic acid purification method | 四川熔增环保科技有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-117865911-A | Preparation method of 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide | 成都科圣原医药科技有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-110317212-B | Synthesis of polycyclic carbamoylpyridone compounds | 吉利德科学公司 | 2022-10-21 | — | — | CN | claimed |
| EP-3527573-B9 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2022-07-06 | — | — | EP | claimed |
| CN-114394983-A | Synthesis of polycyclic carbamoylpyridone compounds | 吉利德科学公司 | 2022-04-26 | — | — | CN | claimed |
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | GILEAD SCIENCES, INC. (US) | 2021-04-13 | — | — | US | claimed |
| EP-3783001-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | Gilead Sciences, Inc. (US) | 2021-02-24 | — | — | EP | claimed |
| EP-3527573-B1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2020-08-12 | — | — | EP | claimed |
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2020-07-16 | — | — | US | claimed |
| CN-110317212-A | The synthesis of polycyclic carbamoylpyridone compound | 吉利德科学公司 | 2019-10-11 | — | — | CN | claimed |
| WO-2015195656-A2 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES ,INC. (US) | 2015-12-23 | — | — | WO | claimed |
| CN-104230782-A | Synthetic method of silodosin | KUNMING JIDA PHARMACEUTICAL CO LTD | 2014-12-24 | — | — | CN | claimed |
| US-20130012736-A1 | METHYLIDENE MALONATE PROCESS | OPTMED, INC. (US) | 2013-01-10 | — | — | US | claimed |
| US-20090124814-A1 | Process for preparing telmisartan | PERLMAN NURIT | 2009-05-14 | — | — | US | claimed |
| EP-1699765-A1 | PROCESS FOR PREPARING TELMISARTAN | Teva Pharmaceutical Industries Ltd (IL) | 2006-09-13 | — | — | EP | claimed |
| US-20060094883-A1 | high yields, low cost process; easy solvent extraction; nontoxic, safe, environmentally friendly, low boiling point organic solvents; 1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl is reacted with 4'bromomethyl-biphenyl-2-carboxylic acid alkyl ester; industrial scale; hydrolysis | TEVA PHARMACEUTICALS USA, INC. | 2006-05-04 | — | — | US | claimed |
| WO-2006044648-A1 | PROCESS FOR PREPARING TELMISARTAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-04-27 | — | — | WO | claimed |
| EP-0035881-B1 | 2,3,4,5,6,7-HEXAHYDRO-10-HYDROXY-2-METHYL-8-PHENYL-8H-FURO(3,2-G)-3-BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1985-07-17 | — | — | EP | claimed |
| EP-0035881-A1 | 2,3,4,5,6,7-Hexahydro-10-hydroxy-2-methyl-8-phenyl-8H-furo(3,2-g)-3-benzazepines, process for their preparation and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1981-09-16 | — | — | EP | claimed |
| US-4255445-A | DOPAMINERGIC ACTIVITY, RENAL VASODILATING ACTIVITY | SMITHKLINE CORPORATION (US) | 1981-03-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | ALDH1A1 883/4885L3MBTL1 4723/4885CA5A 283/4885 |
| US-20130012736-A1 | METHYLIDENE MALONATE PROCESS | MPHOSPH6, ME1, MGAM | ALDH1A1 1618/4885L3MBTL1 958/4885CA5A 4030/4885 |
| US-20060094883-A1 | high yields, low cost process; easy solvent extraction; nontoxic, safe, environmentally friendly, low boiling point organic solvents; 1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl is reacted with 4'bromomethyl-biphenyl-2-carboxylic acid alkyl ester; industrial scale; hydrolysis | AGT, ACE, REN | ALDH1A1 1639/4885L3MBTL1 3642/4885CA5A 3186/4885 |
| US-20090124814-A1 | Process for preparing telmisartan | AGT, ACE, REN | ALDH1A1 2133/4885L3MBTL1 4842/4885CA5A 3842/4885 |
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | CPS1, SDHA, DHPS | ALDH1A1 883/4885L3MBTL1 4723/4885CA5A 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.