Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1548729 | 0.83 | RAB9A (0.59) | MAOAMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL20595853 | 0.79 | L3MBTL1 (0.49) | ACHEHDAC3HDAC1HDAC2HDAC8 | |
| Methyl Benzoate SCHEMBL30924569 | 0.79 | TSHR (0.49) | MAOAACHEMEN1MAPTKMT2A | |
| SCHEMBL3333662 | 0.78 | HDAC3 (0.47) | ACHEHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL14656020 | 0.77 | ACHE (0.64) | MAOAACHEHDAC1HDAC8HDAC6 | |
| SCHEMBL24499052 | 0.76 | CYP2C9 (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL496467 | 0.76 | MAOA (0.50) | MAOAACHEMEN1MAPTKMT2A | |
| SCHEMBL162485 | 0.76 | MAOA (0.50) | MAOAACHEMEN1MAPTKMT2A | |
| SCHEMBL595766 | 0.76 | MAOA (0.50) | MAOAACHEHDAC3HDAC1HDAC2 | |
| SCHEMBL13151287 | 0.75 | CYP1A2 (0.48) | MAOAACHEMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11465997-B2 | Synthesis of disorazoles and analogs thereof as potent anticancer agents | WILLIAM MARSH RICE UNIVERSITY (US) | 2022-10-11 | — | — | US | disclosed |
| US-20210155616-A1 | SYNTHESIS OF DISORAZOLES AND ANALOGS THEREOF AS POTENT ANTICANCER AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-05-27 | — | — | US | disclosed |
| US-20210155616-A1 | SYNTHESIS OF DISORAZOLES AND ANALOGS THEREOF AS POTENT ANTICANCER AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-05-27 | — | — | US | disclosed |
| EP-3641891-A1 | SYNTHESIS OF DISORAZOLES AND ANALOGS THEREOF AS POTENT ANTICANCER AGENTS | William Marsh Rice University (US) | 2020-04-29 | — | — | EP | disclosed |
| WO-2018237178-A1 | SYNTHESIS OF DISORAZOLES AND ANALOGS THEREOF AS POTENT ANTICANCER AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-12-27 | — | — | WO | disclosed |
| US-8344154-B2 | 2-thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20100145063-A1 | 2- thioethenyl substituted carbapenem derivatives | MARUYAMA TAKAHISA | 2010-06-10 | — | — | US | disclosed |
| US-7687490-B2 | 2-thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| CN-101193891-A | 2-thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA (JP) | 2008-06-04 | — | — | CN | disclosed |
| EP-1870412-A1 | 2-THIOETHENYL CARBAPENEM DERIVATIVE | MEIJI SEIKA KAISHA LTD. (JP) | 2007-12-26 | — | — | EP | disclosed |
| US-20070004700-A1 | 2-Thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145063-A1 | 2- thioethenyl substituted carbapenem derivatives | MTAP, BLVRB, TPMT | MAOA 3675/4885ACHE 3382/4885HDAC3 722/4885 |
| US-20070004700-A1 | 2-Thioethenyl substituted carbapenem derivatives | MTAP, BLVRB, BPGM | MAOA 2241/4885ACHE 2739/4885HDAC3 570/4885 |
| US-11465997-B2 | Synthesis of disorazoles and analogs thereof as potent anticancer agents | CD47, DUT, CD99 | MAOA 2004/4885ACHE 4185/4885HDAC3 795/4885 |
| US-20210155616-A1 | SYNTHESIS OF DISORAZOLES AND ANALOGS THEREOF AS POTENT ANTICANCER AGENTS | CD47, DUT, CD99 | MAOA 2004/4885ACHE 4185/4885HDAC3 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.