Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3338330 | 0.88 | DHFR (0.50) | DHFRGUSBALDH1A1MEN1KMT2A | |
| SCHEMBL13425478 | 0.87 | MEN1 (0.55) | DHFRBRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL13302814 | 0.84 | ALDH1A1 (0.59) | DHFRBRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL3344481 | 0.80 | DHFR (0.52) | DHFRGUSBALDH1A1MEN1KMT2A | |
| (S)-Enastron SCHEMBL5177968 | 0.79 | ALDH1A1 (0.72) | DHFRGUSBALDH1A1MEN1KMT2A | |
| SCHEMBL9701173 | 0.78 | DHFR (0.62) | DHFRGUSBALDH1A1GAAKDM4E | |
| SCHEMBL3343387 | 0.78 | DHFR (0.50) | DHFRGUSBALDH1A1MEN1KMT2A | |
| SCHEMBL13302762 | 0.77 | DHFR (0.52) | DHFRGUSBALDH1A1MEN1KMT2A | |
| Dimethylenastron SCHEMBL5178439 | 0.77 | ALDH1A1 (0.65) | DHFRGUSBALDH1A1MEN1KMT2A | |
| SCHEMBL13426046 | 0.74 | KIF11 (0.46) | DHFRBRD4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-06-17 | — | — | US | disclosed |
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-06-17 | — | — | US | disclosed |
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-06-17 | — | — | US | disclosed |
| WO-2006074293-A2 | BICYCLIC DIHYDROPYRIMIDINES AS EG5 INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | KIF5A, KIF5C, KIF5B | DHFR 45/4885GUSB 2340/4885BRD4 887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.