Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448577 | 0.88 | TSHR (0.44) | PIM1PIM2HSD17B10ALDH1A1CNR2 | |
| SCHEMBL3346064 | 0.86 | PIM1 (0.51) | PIM1PIM2CNR2KDRSLC2A1 | |
| SCHEMBL3344574 | 0.83 | ALDH1A1 (0.40) | PIM1PIM2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL3447564 | 0.80 | OPRK1 (0.48) | HSD17B10CNR2MAPK1OPRK1 | |
| SCHEMBL3348625 | 0.80 | CNR2 (0.50) | HSD17B10CNR2MAPK1OPRK1 | |
| SCHEMBL25175693 | 0.80 | KDR (0.49) | HSD17B10ALDH1A1KDM4EGLAGAA | |
| SCHEMBL31481547 | 0.79 | CNR2 (0.46) | HSD17B10CNR2MAPK1OPRK1 | |
| SCHEMBL3348530 | 0.78 | DGAT1 (0.40) | PIM1PIM2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL16828719 | 0.76 | LMNA (0.49) | HSD17B10ALDH1A1KDM4EGAAMAPK1 | |
| SCHEMBL21513341 | 0.76 | CNR2 (0.46) | ALDH1A1CNR2KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |