Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448579 | 0.90 | UCHL1 (0.38) | DGAT1ROCK2KMT2AGSK3AGSK3B | |
| SCHEMBL3450320 | 0.84 | DGAT1 (0.42) | DGAT1ALDH1A1ROCK2ALPLKDM4E | |
| SCHEMBL3377209 | 0.84 | DGAT1 (0.42) | DGAT1ROCK2ALPLTSHRGSK3A | |
| SCHEMBL29604061 | 0.80 | ALPL (0.46) | DGAT1ALDH1A1ROCK2ALPLKDM4E | |
| SCHEMBL789862 | 0.80 | ALPL (0.46) | DGAT1ALDH1A1ROCK2ALPLKDM4E | |
| SCHEMBL3348525 | 0.80 | RORC (0.38) | DGAT1ALDH1A1ROCK2ALPLKDM4E | |
| SCHEMBL3373117 | 0.79 | TBXAS1 (0.42) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL3345812 | 0.78 | PIM1 (0.43) | ALDH1A1KDM4EKMT2AHSD17B10GLA | |
| SCHEMBL3448376 | 0.78 | DGAT1 (0.46) | DGAT1ROCK2ALPLGSK3AGSK3B | |
| SCHEMBL3344574 | 0.76 | ALDH1A1 (0.40) | ALDH1A1KDM4EKMT2AHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |