SCHEMBL3346255

SCHEMBL3346255

O=C(NC1CCCCC1)NC1CCN(C(=O)c2ccccn2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 8/20 1.00
EPHX1 P07099 4/20 0.67
L3MBTL1 Q9Y468 1/20 0.60
EGFR P00533 1/20 0.57
ERBB2 P04626 1/20 0.57
MET P08581 1/20 0.57
KDR P35968 1/20 0.57
MERTK Q12866 1/20 0.57
GRM5 P41594 1/20 0.51
KDM4E B2RXH2 1/20 0.51
MAPT P10636 1/20 0.51
LMNA P02545 1/20 0.50
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8062282 0.86 EPHX2 (0.76) EPHX2EPHX1L3MBTL1EGFRERBB2
SCHEMBL8062288 0.85 EPHX2 (0.74) EPHX2EPHX1L3MBTL1GRM5KDM4E
SCHEMBL4120253 0.83 EPHX2 (0.71) EPHX2EPHX1L3MBTL1KMT2A
SCHEMBL16000514 0.82 EPHX2 (0.69) EPHX2EPHX1L3MBTL1GRM5KMT2A
SCHEMBL16003044 0.81 EPHX2 (0.68) EPHX2EPHX1L3MBTL1
SCHEMBL4009784 0.80 EPHX2 (1.00) EPHX2EPHX1LMNA
SCHEMBL31305639 0.79 L3MBTL1 (0.83) EPHX2L3MBTL1MAPTLMNAKMT2A
SCHEMBL969439 0.79 L3MBTL1 (0.83) EPHX2L3MBTL1MAPTLMNAKMT2A
SCHEMBL3959618 0.79 EPHX2 (0.64) EPHX2
SCHEMBL8063384 0.78 KDM5A (0.70) EPHX2EPHX1L3MBTL1GRM5KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010053829-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS ARETE THERAPEUTICS, INC. (US) 2010-05-14 WO claimed
CN-101679258-A 4-piperidinylurea compounds as soluble epoxide hydrolase inhibitors ARETE THERAPEUTICS INC 2010-03-24 CN claimed
EP-2132176-A1 4-PIPERIDINYLUREA COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS Arete Therapeutics, Inc. (US) 2009-12-16 EP claimed
US-20090270452-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF SMOOTH MUSCLE DISORDERS ARETE THERAPEUTICS, INC. 2009-10-29 US claimed
WO-2009129501-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF SMOOTH MUSCLE DISORDERS ARETE THERAPEUTICS, INC. (US) 2009-10-22 WO claimed
US-20090247521-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION ARETE THERAPEUTICS, INC. 2009-10-01 US claimed
US-20090197916-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS ARETE THERAPEUTICS, INC 2009-08-06 US claimed
WO-2009086426-A2 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION ARETE THERAPEUTICS, INC. (US) 2009-07-09 WO claimed
WO-2008112022-A1 4 -PI PERIDINYLUREA COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS ARETE THERAPEUTICS, INC. (US) 2008-09-18 WO claimed
US-20080227780-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS ARETE THERAPEUTICS, INC. 2008-09-18 US claimed
WO-2010053829-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS ARETE THERAPEUTICS, INC. (US) 2010-05-14 WO disclosed
US-20100063583-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF INFLAMMATORY VASCULAR DISEASES ARETE THERAPEUTICS, INC. 2010-03-11 US disclosed
US-20100063583-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF INFLAMMATORY VASCULAR DISEASES ARETE THERAPEUTICS, INC. 2010-03-11 US disclosed
WO-2010025043-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF INFLAMMATORY VASCULAR DISEASES ARETE THERAPEUTICS, INC. (US) 2010-03-04 WO disclosed
US-20090270452-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF SMOOTH MUSCLE DISORDERS ARETE THERAPEUTICS, INC. 2009-10-29 US disclosed
WO-2009086426-A2 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION ARETE THERAPEUTICS, INC. (US) 2009-07-09 WO disclosed
WO-2008112022-A1 4 -PI PERIDINYLUREA COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS ARETE THERAPEUTICS, INC. (US) 2008-09-18 WO disclosed
US-20080227780-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS ARETE THERAPEUTICS, INC. 2008-09-18 US disclosed
US-20080227780-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS ARETE THERAPEUTICS, INC. 2008-09-18 US disclosed
US-20080227780-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS ARETE THERAPEUTICS, INC. 2008-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247521-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION EPHX1, ECE1, LIPG EPHX2 5/4885EPHX1 1/4885L3MBTL1 4767/4885
US-20090270452-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF SMOOTH MUSCLE DISORDERS EPHX1, PTGIS, PDE3A EPHX2 6/4885EPHX1 1/4885L3MBTL1 4832/4885
US-20100063583-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF INFLAMMATORY VASCULAR DISEASES ALOX15B, ALOX15, ALOX12 EPHX2 6/4885EPHX1 7/4885L3MBTL1 3969/4885
US-20080227780-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS EPHX1, EPHX2, NCEH1 EPHX2 2/4885EPHX1 1/4885L3MBTL1 4706/4885
US-20090197916-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS EPHX1, NCEH1, PNLIP EPHX2 6/4885EPHX1 1/4885L3MBTL1 4519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.