Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346002 | 0.89 | GRIN2D (0.41) | FFAR4DHODHFFAR1GRIN1GRIN2B | |
| SCHEMBL3346086 | 0.87 | PTGER4 (0.44) | DHODHGRIN1GRIN2BRXRARXRB | |
| SCHEMBL3431483 | 0.86 | FFAR1 (0.43) | FFAR4DHODHFFAR1 | |
| SCHEMBL3353013 | 0.82 | DHODH (0.45) | FFAR4DHODHFFAR1GRIN1GRIN2B | |
| SCHEMBL3430044 | 0.80 | FFAR1 (0.48) | FFAR4DHODHFFAR1 | |
| SCHEMBL3430749 | 0.80 | GAA (0.43) | FFAR4DHODHFFAR1GRIN1GRIN2B | |
| SCHEMBL3346056 | 0.79 | S1PR1 (0.41) | FFAR1PDE5ARXRARXRB | |
| SCHEMBL3346903 | 0.78 | GRIN2B (0.36) | FFAR4GRIN1GRIN2BPDE5A | |
| SCHEMBL3431063 | 0.78 | ALDH1A1 (0.39) | FFAR4 | |
| SCHEMBL3346362 | 0.77 | DHODH (0.39) | DHODHGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |