Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 8/20 | 0.39 |
| ▸ | RXRB | P28702 | 8/20 | 0.39 |
| ▸ | RXRG | P48443 | 8/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346289 | 0.85 | PDE5A (0.40) | PDE5APDE9AFFAR1 | |
| SCHEMBL3346903 | 0.84 | GRIN2B (0.36) | PDE5APDE9ANR1H4 | |
| SCHEMBL3431063 | 0.84 | ALDH1A1 (0.39) | GPR17 | |
| SCHEMBL3430892 | 0.83 | FFAR4 (0.44) | PDE5APDE9ACACNA1CFFAR1 | |
| SCHEMBL3346086 | 0.83 | PTGER4 (0.44) | RXRARXRBRXRGGPR17 | |
| SCHEMBL3347691 | 0.79 | FFAR4 (0.40) | RXRARXRBPDE5AFFAR1 | |
| SCHEMBL3431568 | 0.76 | RXRA (0.44) | RXRARXRBRXRGPDE5APDE9A | |
| SCHEMBL3431483 | 0.76 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL3431645 | 0.75 | RXRA (0.43) | RXRARXRBRXRGPDE5APDE9A | |
| SCHEMBL3431683 | 0.73 | RXRA (0.40) | RXRARXRBRXRGPDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | claimed |
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |