Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431063 | 0.90 | ALDH1A1 (0.39) | GCGRPDE3BPDE3AFFAR4 | |
| SCHEMBL3346056 | 0.84 | S1PR1 (0.41) | NR1H4PDE5APDE9A | |
| SCHEMBL3346086 | 0.82 | PTGER4 (0.44) | GRIN2BPARP1GRIN1 | |
| SCHEMBL3347691 | 0.78 | FFAR4 (0.40) | GRIN2BGRIN1FFAR4PDE5A | |
| SCHEMBL3346289 | 0.78 | PDE5A (0.40) | GCGRFFAR4PDE5APDE9A | |
| SCHEMBL3430892 | 0.77 | FFAR4 (0.44) | FFAR4PDE5APDE9A | |
| SCHEMBL3431483 | 0.75 | FFAR1 (0.43) | GCGRFFAR4 | |
| SCHEMBL3353013 | 0.70 | DHODH (0.45) | GRIN2BGRIN1FFAR4 | |
| SCHEMBL3350657 | 0.69 | DHODH (0.41) | — | |
| SCHEMBL3352922 | 0.69 | GSK3B (0.38) | GCGRFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | claimed |
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |