Sugi Predict

Sugi Predict / Compounds / SCHEMBL334884

SCHEMBL334884

SCHEMBL334884

COC(=O)Cc1ccc(CBr)cc1

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CYP4F2 P78329 1/20 0.63
▸ CYP4A11 Q02928 1/20 0.63
▸ HSP90AB1 P08238 1/20 0.52
▸ ALDH1A1 P00352 4/20 0.51
▸ GAA P10253 1/20 0.51
▸ GFER P55789 1/20 0.51
▸ SMN1; SMN2 Q16637 5/20 0.51
▸ NPC1 O15118 4/20 0.51
▸ RAB9A P51151 4/20 0.51
▸ TP53 P04637 2/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ KMT2A Q03164 2/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ MAPT P10636 3/20 0.47
▸ LMNA P02545 2/20 0.47
▸ HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4113212 0.89 CYP4F2 (0.76) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL8158284 0.84 CYP4F2 (0.70) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL502785 0.83 CYP4F2 (0.63) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL14115300 0.83 HSP90AB1 (0.62) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL6288240 0.81 ALDH1A1 (0.56) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL335779 0.81 SLC7A5 (0.59) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL8479488 0.81 GSK3B (0.58) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL9813443 0.81 CYP4A11 (0.66) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL5546570 0.81 CYP4F2 (0.66) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL112297 0.81 CYP4F2 (0.71) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 387 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114591243-A Antipyrine hapten, artificial antigen, antibody and preparation method and application thereof 华南农业大学 2022-06-07 — — CN claimed
CN-106243047-B The double aryl ureas of quinokysalines with VEGFR-2 and B-raf double inhibition effect and its derivative, preparation method and applications 江苏神华药业有限公司 2019-07-23 — — CN claimed
US-9809822-B2 Triptolide derivatives and preparation method and use thereof HONG KONG BAPTIST UNIVERSITY (HK) 2017-11-07 — — US claimed
CN-106243047-A There are the double aryl ureas of quinokysalines and derivant, the preparation method and applications of VEGFR 2 and B raf double inhibition effect 江苏神华药业有限公司 2016-12-21 — — CN claimed
US-12551582-B2 Granzyme B directed imaging and therapy CYTOSITE BIOPHARMA INC. (US) 2026-02-17 — — US disclosed
EP-4665330-A1 PLASMA KALLIKREIN INHIBITORS Merck Sharp & Dohme LLC (US) 2025-12-24 — — EP disclosed
US-12479840-B2 HMG-CoA reductase degradation inducing compound UPPTHERA INC. (KR) 2025-11-25 — — US disclosed
US-20250302815-A1 PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS CALICO LIFE SCIENCES LLC 2025-10-02 — — US disclosed
CN-119930520-A N-aryl pyrazole compound, and pharmaceutical composition and application thereof 中国药科大学 2025-05-06 — — CN disclosed
US-12264169-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners (US) 2025-04-01 — — US disclosed
EP-4526298-A1 PYRAZOLE DERIVATIVES AS STING AGONISTS F. Hoffmann-La Roche AG (CH) 2025-03-26 — — EP disclosed
US-20250084044-A1 PROTOPORPHYRINOGEN OXIDASE INHIBITORS ENKO CHEM, INC. (US) 2025-03-13 — — US disclosed
US-5789409-A ANTIINFLAMMATORY AGENTS SENJU PHARMACEUTICAL CO., LTD. (JP) 1998-08-04 — — US disclosed
US-5776964-A HYPOTENSIVE AGENTS; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 1998-07-07 — — US disclosed
WO-1998008813-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PYRROLIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-03-05 — — WO disclosed
WO-1997026300-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED INDANE LIBRARIES ELI LILLY AND COMPANY (US) 1997-07-24 — — WO disclosed
EP-0753515-A2 Benzylpiperazine derivatives as antiallergic and anti-inflammatory agents Senju Pharmaceutical Co., Ltd. (JP) 1997-01-15 — — EP disclosed
US-5521206-A HYPOTENSIVE AGENTS, TREATMENT OF ATHEROSCLEROSIS BAYER AKTIENGESELLSCHAFT (DE) 1996-05-28 — — US disclosed
US-5374641-A Thromboxane synthetase inhibitors, prostaglandin H2 antagonist , anticoagulants and antiallergens TERUMO KABUSHIKI KAISHA (JP) 1994-12-20 — — US disclosed
EP-0501876-A1 N-(3-pyridylalkyl)sulfonamide derivative and pharmaceutical preparation containing thereof TERUMO KABUSHIKI KAISHA (JP) 1992-09-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250084044-A1 PROTOPORPHYRINOGEN OXIDASE INHIBITORS PPOX, CYP4X1, PNPO CYP4F2 40/4885CYP4A11 188/4885HSP90AB1 1306/4885
US-20250302815-A1 PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS PTPN1, PTPN2, PTPN18 CYP4F2 3110/4885CYP4A11 3592/4885HSP90AB1 517/4885
US-12264169-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C CYP4F2 495/4885CYP4A11 60/4885HSP90AB1 1414/4885
US-12479840-B2 HMG-CoA reductase degradation inducing compound HMGCR, HMGB2, LDLR CYP4F2 378/4885CYP4A11 118/4885HSP90AB1 670/4885
US-12551582-B2 Granzyme B directed imaging and therapy GZMB, PRF1, CTSB CYP4F2 4408/4885CYP4A11 4460/4885HSP90AB1 1492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.