Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3352991 | 1.00 | CDC7 (0.43) | CDC7HTR7SIRT2HSP90AA1ALDH1A1 | |
| SCHEMBL3358552 | 0.81 | HTR7 (0.45) | CDC7HTR7SIRT2HSP90AA1ALDH1A1 | |
| SCHEMBL3353526 | 0.80 | CDC7 (0.43) | CDC7HTR7SIRT2ALDH1A1MAPT | |
| SCHEMBL3357611 | 0.80 | CDC7 (0.43) | CDC7HTR7SIRT2ALDH1A1MAPT | |
| SCHEMBL3357757 | 0.77 | NPC1 (0.47) | CDC7HTR7SIRT2HSP90AA1ALDH1A1 | |
| SCHEMBL13537457 | 0.76 | NOS3 (0.35) | NOS3NOS1NOS2 | |
| SCHEMBL3353782 | 0.75 | ALDH1A1 (0.42) | CDC7HTR7SIRT2ALDH1A1LMNA | |
| SCHEMBL3359093 | 0.75 | ALDH1A1 (0.41) | CDC7HTR7SIRT2ALDH1A1MAPT | |
| SCHEMBL3352450 | 0.74 | HTR7 (0.45) | CDC7HTR7MAPTPOLBNOS3 | |
| SCHEMBL3353280 | 0.74 | HTR7 (0.53) | CDC7HTR7MAPTNOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |