Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR1F | P30939 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12253684 | 0.95 | HTR7 (0.55) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3354240 | 0.90 | HTR7 (0.45) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3354104 | 0.87 | DRD2 (0.60) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3358021 | 0.86 | HTR7 (0.47) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3357415 | 0.86 | HTR7 (0.42) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3355938 | 0.85 | HTR7 (0.52) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL2267614 | 0.85 | NOS3 (0.48) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3357757 | 0.85 | NPC1 (0.47) | HTR7HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3352450 | 0.84 | HTR7 (0.45) | HTR7NOS3NOS1NOS2CDC7 | |
| SCHEMBL3352455 | 0.84 | HTR7 (0.45) | HTR7NOS3NOS1NOS2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |