Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 5/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.42 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416539 | 0.87 | GPR88 (0.45) | GPR88TDP1TAS1R3TAS1R1REN | |
| SCHEMBL3353138 | 0.85 | KCNQ3 (0.52) | KCNQ3KCNQ2KCNQ4KCNQ5LMNA | |
| SCHEMBL3346531 | 0.82 | GPR88 (0.66) | GPR88TDP1KCNQ3KCNQ2 | |
| SCHEMBL3353012 | 0.81 | KCNH2 (0.59) | GPR88TDP1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353295 | 0.79 | GPR88 (0.52) | GPR88TDP1KCNQ3KCNQ2 | |
| SCHEMBL3346676 | 0.77 | KCNQ3 (0.53) | KCNQ3KCNQ2KCNQ4KCNQ5ROCK2 | |
| SCHEMBL3353133 | 0.77 | KCNH2 (0.47) | RENKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346539 | 0.75 | KCNH2 (0.57) | KCNQ3KCNQ2KCNQ4KCNQ5ALDH1A1 | |
| SCHEMBL3353142 | 0.75 | MC4R (0.62) | ALDH1A1HPGDHSD17B10MAPTNPSR1 | |
| SCHEMBL3346373 | 0.75 | KCNH2 (0.57) | KCNQ3KCNQ2KCNQ4KCNQ5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |