SCHEMBL3357458

SCHEMBL3357458

Clc1ccccc1Cc1ccc(Cc2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.55
SIGMAR1 Q99720 1/20 0.50
IDO1 P14902 2/20 0.48
PNMT P11086 1/20 0.48
HTR2A P28223 1/20 0.47
ALDH1A1 P00352 1/20 0.46
MEN1 O00255 1/20 0.46
CYP3A4 P08684 1/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
KMT2A Q03164 1/20 0.46
HIF1A Q16665 1/20 0.46
HSD17B10 Q99714 1/20 0.46
TAAR1 Q96RJ0 2/20 0.45
BCL2 P10415 1/20 0.45
BCL2L1 Q07817 1/20 0.45
LMNA P02545 1/20 0.44
CTRC Q99895 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4423210 0.95 SIGMAR1 (0.53) CALM1SIGMAR1IDO1PNMTHTR2A
SCHEMBL8752818 0.87 SMN1; SMN2 (0.47) SIGMAR1IDO1PNMTHIF1ATAAR1
Methylamine SCHEMBL27625991 0.87 PNMT (0.50) CALM1SIGMAR1IDO1PNMTHTR2A
Bicarbonate SCHEMBL27450694 0.87 RAB9A (0.50) SIGMAR1ALDH1A1MEN1CYP3A4HPGD
SCHEMBL3814505 0.86 MEN1 (0.50) IDO1PNMTALDH1A1MEN1CYP3A4
Benzylamine SCHEMBL28525385 0.85 PNMT (0.59) CALM1SIGMAR1IDO1PNMTHTR2A
SCHEMBL2089904 0.83 KDM4E (0.53) IDO1PNMTALDH1A1MEN1KMT2A
SCHEMBL6299177 0.83 KEAP1 (0.64) IDO1PNMTMEN1KMT2A
SCHEMBL21186239 0.83 ALDH1A1 (0.52) IDO1PNMTHTR2AALDH1A1CYP3A4
SCHEMBL3438629 0.83 TAAR1 (0.47) IDO1PNMTTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8871881-B2 Hydrophobic flourinated coating PHILIPPS-UNIVERSITÄT MARBURG (DE) 2014-10-28 US disclosed
EP-2196491-B1 Hydrophobic fluorinated polymer surfaces PHILIPPS UNIVERSITÄT MARBURG (DE) 2014-08-06 EP disclosed
EP-2267064-B1 Hydrophobic fluorinated polymer surfaces UNIV MARBURG PHILIPPS (DE) 2013-06-26 EP disclosed
EP-2267064-A1 Hydrophobic fluorinated polymer surfaces Philipps-Universität Marburg (DE) 2010-12-29 EP disclosed
EP-2196491-A1 Hydrophobic fluorinated polymer surfaces PHILIPPS-UNIVERSITÄT MARBURG (DE) 2010-06-16 EP disclosed
EP-2048187-A1 Hydrophobic fluorinated polymer surfaces PHILIPPS-UNIVERSITÄT MARBURG (DE) 2009-04-15 EP disclosed
US-20090010870-A1 Hydrophobic Flourinated Polymer Surfaces PHILIPPS-UNIVERSITAT MARBURG (DE) 2009-01-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090010870-A1 Hydrophobic Flourinated Polymer Surfaces HGF, PFN1, HACD3 CALM1 3529/4885SIGMAR1 152/4885IDO1 1897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.