Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | FABP6 | P51161 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336443 | 0.89 | SMN1; SMN2 (0.43) | RAB9ASMN1; SMN2ACP1NPC1MAPT | |
| SCHEMBL335390 | 0.86 | ABL1 (0.44) | RAB9ASMN1; SMN2ACP1ALDH1A1NPC1 | |
| SCHEMBL15282212 | 0.86 | ACP1 (0.46) | RAB9ASMN1; SMN2ACP1ALDH1A1NPC1 | |
| SCHEMBL15282285 | 0.86 | ACP1 (0.46) | RAB9ASMN1; SMN2ACP1ALDH1A1NPC1 | |
| SCHEMBL335316 | 0.85 | ALOX15 (0.41) | — | |
| SCHEMBL335351 | 0.85 | EGFR (0.50) | RAB9ASMN1; SMN2ACP1HDAC1ALDH1A1 | |
| SCHEMBL336367 | 0.84 | MAPT (0.47) | RAB9ASMN1; SMN2ACP1ALDH1A1NPC1 | |
| SCHEMBL335948 | 0.84 | ABL1 (0.45) | RAB9ASMN1; SMN2ACP1HDAC1ALDH1A1 | |
| SCHEMBL335570 | 0.83 | PIN1 (0.47) | RAB9AACP1HDAC1MAPTABL1 | |
| SCHEMBL335878 | 0.82 | ABL1 (0.43) | SMN1; SMN2ACP1HDAC1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097758-B2 | Isoserine derivatives for use as coagulation factor IXa inhibitors | SANOFI-AVENTIS (FR) | 2012-01-17 | — | — | US | claimed |