Sugi Predict

Sugi Predict / Compounds / Prostaglandin A1

Prostaglandin A1

Prostaglandin A1

SCHEMBL3366007

CCCCC[C@H](O)/C=C/[C@H]1C=CC(=O)C1CCCCCCC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPA1 O75762 4/20 1.00
▸ NR4A2 P43354 3/20 1.00
▸ MEN1 O00255 2/20 0.72
▸ LMNA P02545 2/20 0.72
▸ HPGD P15428 2/20 0.72
▸ KMT2A Q03164 2/20 0.72
▸ HIF1A Q16665 2/20 0.72
▸ ALDH1A1 P00352 2/20 0.72
▸ POLB P06746 1/20 0.72
▸ NR4A1 P22736 1/20 0.72
▸ PTPN7 P35236 1/20 0.72
▸ SMN1; SMN2 Q16637 1/20 0.72
▸ PTGER4 P35408 5/20 0.64
▸ PTGER2 P43116 3/20 0.64
▸ PTGIR P43119 3/20 0.64
▸ TSHR P16473 2/20 0.64
▸ CYP3A4 P08684 1/20 0.64
▸ MAPK1 P28482 1/20 0.64
▸ ABCC3 O15438 1/20 0.64
▸ ABCC4 O15439 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Prostaglandin A1 SCHEMBL6417551 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL11650631 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL17914205 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL8347686 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL14577651 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL23717317 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL6417548 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL13649323 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL22425783 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD
Prostaglandin A1 SCHEMBL8347690 1.00 TRPA1 (1.00) TRPA1NR4A2MEN1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230174476-A1 HIGH PENETRATION PRODRUG COMPOSITIONS OF PROSTAGLANDINS AND RELATED COMPOUNDS TECHFIELDS PHARMA CO., LTD. (CN) 2023-06-08 — — US disclosed
US-20200038352-A1 CO-CRYSTALS OF NURR1-LBD IN COMPLEX WITH A CYCLOPENTENONE PROSTAGLANDIN AND MODULATORS OF NURR1 NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2020-02-06 — — US disclosed
EP-3195857-A1 USE OF A TRP MODULATOR FOR THE PROPHYLAXIS AND/OR ALLEVIATING OF GRASS TETANY AND/OR PARTURIENT PARESIS IN TYLOPODA OR RUMINANTS Freie Universität Berlin (DE) 2017-07-26 — — EP disclosed
US-9693971-B2 Compositions for alleviating gastrointestinal tract disorders or associated systemic disorders in ruminants and camelids FREIE UNIVERSITÄT BERLIN (DE) 2017-07-04 — — US disclosed
EP-2879662-B1 COMPOSITION FOR ALLEVIATING GASTROINTESTINAL DEFECTS OR SYSTEMIC SYMPTOMES ASSOCIATED HEREWITH IN RUMINANTS AND CAMELIDS FREIE UNIVERSITÄT BERLIN (DE) 2017-02-08 — — EP disclosed
US-20150164822-A1 COMPOSITIONS FOR ALLEVIATING GASTROINTESTINAL TRACT DISORDERS OR ASSOCIATED SYSTEMIC DISORDERS IN RUMINANTS AND CAMELIDS PERFORMANAT GMBH (DE) 2015-06-18 — — US disclosed
EP-2879662-A1 COMPOSITIONS FOR ALLEVIATING GASTROINTESTINAL TRACT DISORDERS OR ASSOCIATED SYSTEMIC DISORDERS IN RUMINANTS AND CAMELIDS Freie Universität Berlin (DE) 2015-06-10 — — EP disclosed
US-8722739-B2 Amino acid salts of prostaglandins NOVAER HOLDINGS, INC. (US) 2014-05-13 — — US disclosed
WO-2014020067-A1 COMPOSITIONS FOR ALLEVIATING GASTROINTESTINAL TRACT DISORDERS OR ASSOCIATED SYSTEMIC DISORDERS IN RUMINANTS AND CAMELIDS FREIE UNIVERSITÄT BERLIN (DE) 2014-02-06 — — WO disclosed
US-20140031423-A1 AMINO ACID SALTS OF PROSTAGLANDINS NOVAER HOLDINGS, INC. (US) 2014-01-30 — — US disclosed
US-8623918-B2 Amino acid salts of prostaglandins NOVAER HOLDINGS, INC. (US) 2014-01-07 — — US disclosed
US-8470882-B2 — — 2013-06-25 — — US disclosed
US-20100105771-A1 AMINO ACID SALTS OF PROSTAGLANDINS NOVAER HOLDINGS, INC. 2010-04-29 — — US disclosed
US-20100105775-A1 AMINO ACID SALTS OF PROSTAGLANDINS NOVAER HOLDINGS, INC. 2010-04-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174476-A1 HIGH PENETRATION PRODRUG COMPOSITIONS OF PROSTAGLANDINS AND RELATED COMPOUNDS HPGDS, PTGER1, PTGIS TRPA1 944/4885NR4A2 1828/4885MEN1 3170/4885
US-20100105771-A1 AMINO ACID SALTS OF PROSTAGLANDINS PTGIS, PTGES, PTGIR TRPA1 1223/4885NR4A2 4579/4885MEN1 3153/4885
US-20100105775-A1 AMINO ACID SALTS OF PROSTAGLANDINS PTGIS, PTGES, PTGIR TRPA1 1223/4885NR4A2 4579/4885MEN1 3153/4885
US-20140031423-A1 AMINO ACID SALTS OF PROSTAGLANDINS PTGIS, PTGES, PTGIR TRPA1 1223/4885NR4A2 4579/4885MEN1 3153/4885
US-20200038352-A1 CO-CRYSTALS OF NURR1-LBD IN COMPLEX WITH A CYCLOPENTENONE PROSTAGLANDIN AND MODULATORS OF NURR1 NCOR1, NCOA1, NR0B1 TRPA1 2781/4885NR4A2 13/4885MEN1 4811/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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