Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 4/20 | 1.00 |
| ▸ | PDPK1 | O15530 | 1/20 | 1.00 |
| ▸ | PAK1 | Q13153 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 6/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | AKT2 | P31751 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.71 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.71 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.68 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898244 | 0.88 | HTT (0.86) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL12048138 | 0.88 | HTT (0.86) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL6755685 | 0.88 | HTT (0.86) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL9095854 | 0.85 | HTT (1.00) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL3287249 | 0.83 | HTT (1.00) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL1030420 | 0.82 | HTT (0.76) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL2301186 | 0.80 | HTT (0.75) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL31713036 | 0.78 | PTK2B (1.00) | MAPK1CHEK1PDPK1PAK1HTT | |
| SCHEMBL3322529 | 0.78 | CHEK1 (0.64) | MAPK1CHEK1PDPK1PAK1SRC | |
| SCHEMBL12048165 | 0.78 | HTT (0.69) | MAPK1CHEK1PDPK1PAK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11541060-B2 | Pharmaceutical compositions for treating pain | Forever Cheer Holding Limited (HK) | 2023-01-03 | — | — | US | claimed |
| US-20180333420-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN | FOREVER CHEER INTERNATIONAL LTD (HK) | 2018-11-22 | — | — | US | claimed |
| EP-3403674-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN | Forever Cheer International Limited (HK) | 2018-11-21 | — | — | EP | claimed |
| US-20230149295-A1 | INFLAMMATORY BOWEL DISEASE STEM CELLS, AGENTS WHICH TARGET IBD STEM CELLS, AND USES RELATED THERETO | UNIVERSITY OF HOUSTON SYSTEM (US) | 2023-05-18 | — | — | US | disclosed |
| EP-4121111-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY AND FIBROTIC PULMONARY DISORDERS | University of Houston System (US) | 2023-01-25 | — | — | EP | disclosed |
| EP-4117718-A1 | INFLAMMATORY BOWEL DISEASE STEM CELLS, AGENTS WHICH TARGET IBD STEM CELLS, AND USES RELATED THERETO | University of Houston System (US) | 2023-01-18 | — | — | EP | disclosed |
| US-11541060-B2 | Pharmaceutical compositions for treating pain | Forever Cheer Holding Limited (HK) | 2023-01-03 | — | — | US | disclosed |
| US-20210401987-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY AND FIBROTIC PULMONARY DISORDERS | UNIVERSITY OF HOUSTON SYSTEM (US) | 2021-12-30 | — | — | US | disclosed |
| US-20210379021-A1 | METHOD FOR PREPARING AND DELIVERING BISANTRENE FORMULATIONS | RACE ONCOLOGY LTD (AU) | 2021-12-09 | — | — | US | disclosed |
| US-11147800-B2 | Combinatorial methods to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof | RACE ONCOLOGY LTD. (AU) | 2021-10-19 | — | — | US | disclosed |
| US-11135201-B2 | Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof | RACE ONCOLOGY LTD. (AU) | 2021-10-05 | — | — | US | disclosed |
| US-5977061-A | VIRICIDE AGAINST DNA VIRUSES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1999-11-02 | — | — | US | disclosed |
| EP-0821690-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky (CZ) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033200-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AKADEMIE VED C^¿ESKÉ REPUBLIKY (CZ) | 1996-10-24 | — | — | WO | disclosed |
| EP-0286425-B1 | Therapeutic nucleosides | WELLCOME FOUND (GB) | 1995-01-11 | — | — | EP | disclosed |
| US-5185437-A | 6-substituted 2',3'-dideoxypurine nucleosides; treatment for human immunodeficiency virus and heptatis b virus | BURROUGHS WELLCOME CO. (US) | 1993-02-09 | — | — | US | disclosed |
| US-5068320-A | 2-amino-6-(cyclopropylamino)purine-9-β-D-2',3'-dideoxyribofuranoside and its pharmaceutically acceptable salts | BURROUGHS WELLCOME CO. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0421819-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-04-10 | — | — | EP | disclosed |
| EP-0286425-A2 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-10-12 | — | — | EP | disclosed |
| US-3996361-A | ANTIEDEMATOUS, REDUCING CAPILLARY PERMEABILITY | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210401987-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY AND FIBROTIC PULMONARY DISORDERS | MMP1, MMP8, CCL11 | MAPK1 1692/4885CHEK1 4589/4885PDPK1 1480/4885 |
| US-11135201-B2 | Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof | CYP3A43, HCCS, MCL1 | MAPK1 4301/4885CHEK1 666/4885PDPK1 2606/4885 |
| US-11147800-B2 | Combinatorial methods to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof | CYP3A43, CYP11B1, MCL1 | MAPK1 4193/4885CHEK1 936/4885PDPK1 2183/4885 |
| US-20230149295-A1 | INFLAMMATORY BOWEL DISEASE STEM CELLS, AGENTS WHICH TARGET IBD STEM CELLS, AND USES RELATED THERETO | EPCAM, FABP2, TPMT | MAPK1 1351/4885CHEK1 4459/4885PDPK1 2566/4885 |
| US-20210379021-A1 | METHOD FOR PREPARING AND DELIVERING BISANTRENE FORMULATIONS | CYP3A43, CYP1A1, UGT1A3 | MAPK1 4385/4885CHEK1 4354/4885PDPK1 3450/4885 |
| US-11541060-B2 | Pharmaceutical compositions for treating pain | OPRM1, OPRL1, OPRD1 | MAPK1 264/4885CHEK1 4715/4885PDPK1 1205/4885 |
| US-20180333420-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN | OPRM1, OPRL1, OPRD1 | MAPK1 264/4885CHEK1 4715/4885PDPK1 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.