SCHEMBL33732

SCHEMBL33732

Cc1cc2[nH]c(C)nn2n1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CYP1A2 P05177 2/20 0.35
PARP1 P09874 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
POLB P06746 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
ALOX15 P16050 1/20 0.31
SLC11A2 P49281 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
GLA P06280 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6808230 0.78 KDM4E (0.35) KDM4EALDH1A1HPGDLMNA
SCHEMBL2267643 0.75 KDM4E (0.33) KDM4EALDH1A1HPGDHSD17B10CYP1A2
SCHEMBL12617622 0.67
SCHEMBL15295089 0.66 KMT2A (0.50) KDM4EALDH1A1HPGDCYP1A2NPC1
SCHEMBL2269718 0.62 KDM4E (0.35) KDM4EALDH1A1HPGDHSD17B10CYP1A2
SCHEMBL461719 0.58 NPC1 (0.59) KDM4EALDH1A1HPGDHSD17B10CYP1A2
SCHEMBL1841239 0.58 KDM4E (0.39) KDM4EALDH1A1HPGDHSD17B10CYP1A2
SCHEMBL10887727 0.58 KDM4E (0.39) KDM4EALDH1A1HPGDHSD17B10CYP1A2
SCHEMBL14409569 0.58
SCHEMBL18799894 0.55

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1463 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11555017-B2 Oxidation base derived from 1-hexyl-4,5-diaminopyrazole, composition containing same and use thereof in oxidation dyeing of keratin fibres L'OREAL (FR) 2023-01-17 US claimed
US-20220183940-A1 DYEING PROCESS USING PEROXYGENATED SALTS AND A SUBSTRATE COMPRISING OXIDATION DYES L'OREAL (FR) 2022-06-16 US claimed
CN-112089633-A Oxidation dyeing method 莱雅公司 2020-12-18 CN claimed
US-20200392088-A1 NOVEL OXIDATION BASE DERIVED FROM 1-HEXYL-4,5- DIAMINOPYRAZOLE, COMPOSITION CONTAINING SAME AND USE THEREOF IN OXIDATION DYEING OF KERATIN FIBRES L'OREAL (FR) 2020-12-17 US claimed
EP-3687978-A1 PARA-PHENYLENEDIAMINE BASES WITH CATIONIC HETEROCYCLES, AND THE USE OF SAME FOR OXIDATION DYEING KERATIN FIBRES L'Oreal (FR) 2020-08-05 EP claimed
EP-3687970-A1 PARA-PHENYLENEDIAMINE BASES WITH AN ALIPHATIC CHAINE AND TRIALKYL AMMONIUM GROUP, AND THE USE OF SAME FOR OXIDATION DYEING KERATIN FIBRES L'Oreal (FR) 2020-08-05 EP claimed
EP-3464247-B1 NOVEL OXIDATION BASE DERIVED FROM 1-HEXYL-4,5- DIAMINOPYRAZOLE, COMPOSITION CONTAINING SAME AND USE THEREOF IN OXIDATION DYEING OF KERATIN FIBRES OREAL (FR) 2020-03-11 EP claimed
WO-2019063696-A1 PARA-PHENYLENEDIAMINE BASES WITH CATIONIC HETEROCYCLES, AND THE USE OF SAME FOR OXIDATION DYEING KERATIN FIBRES L' OREAL (FR) 2019-04-04 WO claimed
WO-2019063695-A1 PARA-PHENYLENEDIAMINE BASES WITH AN ALIPHATIC CHAINE AND TRIALKYL AMMONIUM GROUP, AND THE USE OF SAME FOR OXIDATION DYEING KERATIN FIBRES L'OREAL (FR) 2019-04-04 WO claimed
WO-2019063611-A1 OXIDATION DYEING PROCESS USING A COUPLER AND A PEROXYGENATED SALT AS OXIDIZING AGENT L'OREAL (FR) 2019-04-04 WO claimed
US-6395042-B1 OXIDATION BASE, HETEROCYCLIC COUPLERS FOR OXIDATION COLOR DYE L'ORÉAL (FR) 2002-05-28 US claimed
US-20020053111-A1 Compositions for oxidation dyeing keratinous fibers comprising at least one 1-(4-aminophenyl) pyrrolidine and at least one cationic polymer,and dyeing methods KRAVTCHENKO SYLVAIN (FR) 2002-05-09 US claimed
US-6379397-B2 CAPABLE OF GENERATING INTENSE COLORINGS IN VARIED SHADES L'OREAL S.A. (FR) 2002-04-30 US claimed
US-20020026675-A1 Compositions for oxidation dyeing keratinous fibers comprising at least one 1-(4-aminophenyl)pyrrolidine and at least one thickening polymer comprising at least one sugar unit, and dyeing methods KRAVTCHENKO SYLVAIN (FR) 2002-03-07 US claimed
US-20020020029-A1 Composition for the oxidation dyeing of keratinous fibers comprising at least one 1-(4-aminophenyl)pyrrolidine oxidation dye and at least one enzymatic oxidizing system, and dyeing methods L'OREAL S.A. (FR) 2002-02-21 US claimed
US-20020007520-A1 COMPOSITIONS FOR DYEING KERATINOUS FIBERS COMPRISING PYRAZOLOAZOLES; THEIR USE IN DYEING AS OXIDATION BASE AND DYEING PROCESS; AND NOVEL PYRAZOLOAZOLES L'OREAL S.A. (FR) 2002-01-24 US claimed
US-20020007523-A1 Compositions for dyeing keratinous fibres, containing pyrazolo-azoles; their use for dyeing, as couplers; method of dyeing L' OREAL S.A. 2002-01-24 US claimed
EP-1047379-B1 COMPOSITION FOR THE OXIDATIVE DYEING OF KERATINIC FIBERS COMPRISING A LACCASE AND DEYING PROCESS USING SUCH A COMPOSITION OREAL (FR) 2001-10-10 EP claimed
EP-1047377-B1 DYEING COMPOSITION CONTAINING A LACCASE AND KERATINOUS FIBRE DYEING METHODS USING SAME OREAL (FR) 2001-06-27 EP claimed
US-6231623-B1 OXIDATIVE DYES L'OREAL S.A. (FR) 2001-05-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020053111-A1 Compositions for oxidation dyeing keratinous fibers comprising at least one 1-(4-aminophenyl) pyrrolidine and at least one cationic polymer,and dyeing methods KRT18, PYCR1, PLOD1 KDM4E 850/4885ALDH1A1 221/4885HPGD 312/4885
US-20020020029-A1 Composition for the oxidation dyeing of keratinous fibers comprising at least one 1-(4-aminophenyl)pyrrolidine oxidation dye and at least one enzymatic oxidizing system, and dyeing methods ALDH7A1, KRT18, PPOX KDM4E 670/4885ALDH1A1 43/4885HPGD 265/4885
US-20200392088-A1 NOVEL OXIDATION BASE DERIVED FROM 1-HEXYL-4,5- DIAMINOPYRAZOLE, COMPOSITION CONTAINING SAME AND USE THEREOF IN OXIDATION DYEING OF KERATIN FIBRES KRT18, ALK, AOC1 KDM4E 860/4885ALDH1A1 77/4885HPGD 1202/4885
US-20020007520-A1 COMPOSITIONS FOR DYEING KERATINOUS FIBERS COMPRISING PYRAZOLOAZOLES; THEIR USE IN DYEING AS OXIDATION BASE AND DYEING PROCESS; AND NOVEL PYRAZOLOAZOLES KRT18, ZYX, TUBB3 KDM4E 1907/4885ALDH1A1 264/4885HPGD 806/4885
US-20220183940-A1 DYEING PROCESS USING PEROXYGENATED SALTS AND A SUBSTRATE COMPRISING OXIDATION DYES KRT18, PPOX, PRDX5 KDM4E 1488/4885ALDH1A1 913/4885HPGD 198/4885
US-20020026675-A1 Compositions for oxidation dyeing keratinous fibers comprising at least one 1-(4-aminophenyl)pyrrolidine and at least one thickening polymer comprising at least one sugar unit, and dyeing methods KRT18, HKDC1, PLOD1 KDM4E 485/4885ALDH1A1 154/4885HPGD 1058/4885
US-20020007523-A1 Compositions for dyeing keratinous fibres, containing pyrazolo-azoles; their use for dyeing, as couplers; method of dyeing KRT18, ZYX, CBR3 KDM4E 1287/4885ALDH1A1 650/4885HPGD 1918/4885
US-11555017-B2 Oxidation base derived from 1-hexyl-4,5-diaminopyrazole, composition containing same and use thereof in oxidation dyeing of keratin fibres KRT18, ALK, AOC1 KDM4E 864/4885ALDH1A1 63/4885HPGD 925/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.