Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 3/20 | 0.78 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.78 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11932410 | 0.89 | CRHBP (0.61) | CRHBPCRHR2HSP90AA1CYP19A1ALDH1A1 | |
| SCHEMBL8309888 | 0.87 | CRHBP (1.00) | CRHBPCRHR2HSP90AA1CYP19A1ALDH1A1 | |
| SCHEMBL6368961 | 0.87 | CRHBP (0.68) | CRHBPCRHR2HSP90AA1CYP19A1ALDH1A1 | |
| SCHEMBL9515445 | 0.87 | CRHBP (0.74) | CRHBPCRHR2HSP90AA1CYP19A1ALDH1A1 | |
| SCHEMBL11740810 | 0.86 | CRHBP (0.67) | CRHBPCRHR2HSP90AA1CYP19A1ALDH1A1 | |
| SCHEMBL10531035 | 0.84 | CRHBP (0.75) | CRHBPCRHR2HSP90AA1ALDH1A1LMNA | |
| SCHEMBL397429 | 0.84 | CRHBP (0.67) | CRHBPCRHR2HSP90AA1ALDH1A1NHERF1 | |
| SCHEMBL30680186 | 0.84 | CRHBP (0.67) | CRHBPCRHR2HSP90AA1ALDH1A1NHERF1 | |
| SCHEMBL10825507 | 0.84 | MCL1 (0.60) | CRHBPCRHR2HSP90AA1ALDH1A1LMNA | |
| SCHEMBL28728720 | 0.84 | CRHBP (0.61) | CRHBPCRHR2HSP90AA1CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160304-A1 | AROMATIC SULFONE COMPOUND AS ALDOSTERONE RECEPTOR MODULATOR | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2010-06-24 | — | — | US | disclosed |
| EP-1844768-A1 | AROMATIC SULFONE COMPOUND AS ALDOSTERONE RECEPTOR MODULATOR | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2007-10-17 | — | — | EP | disclosed |
| US-20040023938-A1 | Sulfonamide derivatives | TABUCHI TAKANORI (JP) | 2004-02-05 | — | — | US | disclosed |
| US-6586617-B1 | Nontoxic microbiocides such as 4'-chloro-N-ethyl-2'-nitro-p-toluenesulfonanilide, for agricultural or horticultural, prepared by alkylation or nitration | SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) | 2003-07-01 | — | — | US | disclosed |
| EP-1174028-A1 | SULFONAMIDE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2002-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160304-A1 | AROMATIC SULFONE COMPOUND AS ALDOSTERONE RECEPTOR MODULATOR | NR3C2, AGTR1, AGTR2 | CRHBP 1267/4885CRHR2 67/4885HSP90AA1 2809/4885 |
| US-20040023938-A1 | Sulfonamide derivatives | FPR1, MRM1, SULT1E1 | CRHBP 3949/4885CRHR2 1602/4885HSP90AA1 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.