Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10834173 | 0.81 | AGTR1 (0.65) | PKMKDM4EAGTR1HTTSMN1; SMN2 | |
| SCHEMBL6943431 | 0.78 | CYP11B1 (0.57) | PKMKDM4EAGTR1HTTSMN1; SMN2 | |
| SCHEMBL11370935 | 0.78 | HTT (0.49) | PKMKDM4EAGTR1POLBHTT | |
| SCHEMBL4653156 | 0.78 | AGTR1 (0.57) | PKMKDM4EAGTR1HTTSMN1; SMN2 | |
| SCHEMBL29277555 | 0.77 | HTT (0.49) | PKMKDM4EAGTR1POLBHTT | |
| SCHEMBL10979591 | 0.77 | HTR6 (0.50) | PKMKDM4EAGTR1POLBHTT | |
| SCHEMBL11711743 | 0.75 | MEN1 (0.61) | PKMKDM4EAGTR1HTTSMN1; SMN2 | |
| SCHEMBL21028305 | 0.74 | KDM4E (1.00) | PKMKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1465207 | 0.74 | NFE2L2 (0.42) | PKMKDM4EPOLBHTTSMN1; SMN2 | |
| SCHEMBL8038232 | 0.74 | CYP11B1 (0.60) | PKMKDM4EAGTR1SMN1; SMN2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476428-B1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2010-11-17 | — | — | EP | disclosed |
| EP-0882713-B1 | PROCESS FOR PREPARING HALOGENOPYRIDINE DERIVATIVES | KURARAY CO (JP) | 2008-11-12 | — | — | EP | disclosed |
| US-6855709-B2 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1476428-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | disclosed |
| US-20030186968-A1 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY | 2003-10-02 | — | — | US | disclosed |
| WO-2003072548-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
| CN-1115333-C | Method for producing 2-sulfonylpyridine derivatives and method for producing 2-{[(2-pyridyl) methyl] thio}-1H-benzimidazole derivatives | KURARAY CO (JP) | 2003-07-23 | — | — | CN | disclosed |
| EP-0931790-B1 | Method for producing 2-sulfonylpyridine derivates and method for producing 2-( (2-pyridyl)methyl)thio)-1H-benzimidazole derivates | KURARAY CO (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6350876-B2 | REACTING SULFONYL CYANIDE DERIVATIVE WITH ALPHA,BETA-UNSAT-URATED CARBONYL COMPOUND; ORGANOLITHIUM COMPOUND; STARTING MATERIAL/INTERMEDIATE FOR DRUG SYNTHESIS (ANTI-PARKINSON'S DRUG LAZABEMIDE) AND AGRICULTURAL CHEMICALS (PESTICIDES) | KURARAY CO., LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| US-20010051726-A1 | Method for producing 2-sulfonylpyridine derivatives and method for producing 2- { [ (2-pyridyl) methyl] thio} -1H-benzimidazole derivatives | KURARAY CO., LTD. (JP) | 2001-12-13 | — | — | US | disclosed |
| US-6197962-B1 | REACTING A,B-UNSATURATED CARBONYL COMPOUND WITH A SULFONYL CYANIDE; CYCLIZATION | KURARAY CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| US-6118005-A | Process for preparing halogenopyridine derivatives | KURARAY CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| CN-1233613-A | Method for producing 2-sulfonylpyridine derivatives and method for producing 2-{[(2-pyridyl) methyl] thio}-1H-benzimidazole derivatives | KURARAY CO (JP) | 1999-11-03 | — | — | CN | disclosed |
| EP-0931790-A2 | Method for producing 2-sulfonylpyridine derivates and method for producing 2-( (2-pyridyl)methyl)thio)-1H-benzimidazole derivates | KURARAY CO., LTD. (JP) | 1999-07-28 | — | — | EP | disclosed |
| EP-0882713-A1 | PROCESS FOR PREPARING HALOGENOPYRIDINE DERIVATIVES | KURARAY CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186968-A1 | Pyridyl sulfone derivatives | HTR6, TPH1, HTR1A | PKM 1189/4885KDM4E 2658/4885AGTR1 259/4885 |
| US-20010051726-A1 | Method for producing 2-sulfonylpyridine derivatives and method for producing 2- { [ (2-pyridyl) methyl] thio} -1H-benzimidazole derivatives | PDXK, KCNJ2, KCNJ1 | PKM 168/4885KDM4E 1456/4885AGTR1 2234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.