Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377180 | 0.78 | PKM (0.59) | HTTSMN1; SMN2AGTR1HTR6PKM | |
| SCHEMBL11523904 | 0.78 | AGTR1 (0.49) | HTTSMN1; SMN2AGTR1HTR6KDM4E | |
| SCHEMBL30094555 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2HTR6PKMALDH1A1TDP1 | |
| SCHEMBL2568189 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2HTR6PKMALDH1A1TDP1 | |
| SCHEMBL10834173 | 0.73 | AGTR1 (0.65) | HTTSMN1; SMN2AGTR1HTR6PKM | |
| SCHEMBL27975420 | 0.73 | HTT (0.47) | HTTSMN1; SMN2AGTR1HTR6PKM | |
| SCHEMBL11277571 | 0.73 | HTT (0.51) | HTTSMN1; SMN2AGTR1HTR6PKM | |
| SCHEMBL13506044 | 0.72 | HTR6 (0.48) | SMN1; SMN2AGTR1HTR6PKMKDM4E | |
| SCHEMBL1573955 | 0.72 | TSHR (0.48) | HTTSMN1; SMN2AGTR1HTR6PKM | |
| SCHEMBL7301533 | 0.72 | GAA (0.53) | HTTSMN1; SMN2AGTR1HTR6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293552-A | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |