SCHEMBL3377550

SCHEMBL3377550

O=C(c1cnc(Nc2ccc(Cl)cc2Cl)nc1C(F)(F)F)N1CCOCC1

nearest known ligand 0.65

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 5/20 0.65
LRRK2 Q5S007 15/20 0.59
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2C9 P11712 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29510127 1.00 CNR2 (0.65) CNR2LRRK2CYP1A2CYP3A4CYP2C9
SCHEMBL3380963 0.92 CNR2 (0.65) CNR2LRRK2CYP1A2CYP3A4CYP2C9
SCHEMBL12796229 0.85 CNR2 (0.50) CNR2LRRK2CYP1A2CYP3A4CYP2C9
SCHEMBL29509939 0.85 CNR2 (0.65) CNR2LRRK2CYP1A2CYP2C9
SCHEMBL3379847 0.85 CNR2 (0.65) CNR2LRRK2CYP1A2CYP2C9
SCHEMBL3378797 0.85 CNR2 (0.65) CNR2CYP1A2CYP3A4CYP2C9
SCHEMBL3380961 0.84 CNR2 (0.63) CNR2LRRK2CYP1A2CYP3A4CYP2C9
SCHEMBL3377682 0.83 CNR2 (0.65) CNR2LRRK2CYP1A2CYP3A4CYP2C9
SCHEMBL3380965 0.82 CNR2 (0.57) CNR2LRRK2CYP1A2CYP3A4CYP2C9
SCHEMBL3378860 0.81 CNR2 (0.62) CNR2CYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1878725-B1 Pyrimidine derivatives and their use as CB2 modulators GLAXO GROUP LTD (GB) 2010-11-24 EP claimed
US-20250268861-A1 N-ACYLATED FATTY AMINO ACIDS TO REDUCE ABSORPTION VARIABILITY IN CANNABINOID BASED COMPOSITIONS SPOKE SCIENCES, INC. (US) 2025-08-28 US disclosed
US-12303487-B2 N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions SPOKE SCIENCES, INC. (US) 2025-05-20 US disclosed
US-20250152509-A1 PARTICLES, AQUEOUS DISPERSIONS, AND LIQUID COMPOSITIONS HAVING HIGH LIPOPHILIC COMPONENT CONCENTRATIONS AND HIGH LIPOPHILIC COMPONENT TO SURFACTANT RATIOS SPOKE SCIENCES, INC. (US) 2025-05-15 US disclosed
US-20240261303-A1 PARTICLES, AQUEOUS DISPERSIONS, AND COMPOSITIONS HAVING HIGH LIPOPHILIC COMPONENT CONCENTRATIONS AND HIGH LIPOPHILIC COMPONENT TO SURFACTANT RATIOS SPOKE SCIENCES, INC. 2024-08-08 US disclosed
US-20240009208-A1 STABILIZATION OF CANNABINOIDS WITHIN SOLID DOSAGE FORMS RECEPTOR HOLDINGS, INC. (US) 2024-01-11 US disclosed
WO-2023201303-A2 SYSTEMS AND METHODS TO AUTOMATICALLY ADMINISTER A PSYCHOACTIVE SUBSTANCE TO AN AIRWAY OF A USER BASED ON A DETECTED EVENT OR CONDITION Green Sky Creations, LLC (US) 2023-10-19 WO disclosed
US-20230293479-A1 MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS RECEPTOR HOLDINGS, INC. (US) 2023-09-21 US disclosed
WO-2023102134-A2 PARTICLES, AQUEOUS DISPERSIONS, AND LIQUID COMPOSITIONS HAVING HIGH LIPOPHILIC COMPONENT CONCENTRATIONS AND HIGH LIPOPHILIC COMPONENT TO SURFACTANT RATIOS SPOKE SCIENCES, INC. (US) 2023-06-08 WO disclosed
US-11670410-B1 Systems and methods to automatically administer a psychoactive substance to an airway of a user based on a detected event or condition Green Sky Creations LLC (US) 2023-06-06 US disclosed
US-7635701-B2 Pyrimidine derivatives and their use as CB2 modulators GLAXO GROUP LIMITED (GB) 2009-12-22 US disclosed
US-7635701-B2 Pyrimidine derivatives and their use as CB2 modulators GLAXO GROUP LIMITED (GB) 2009-12-22 US disclosed
US-20080132505-A1 Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine GLAXO GROUP LIMITED 2008-06-05 US disclosed
EP-1878725-A2 Pyrimidine derivatives and their use as CB2 modulators GLAXO GROUP LIMITED (GB) 2008-01-16 EP disclosed
EP-1878725-A2 Pyrimidine derivatives and their use as CB2 modulators GLAXO GROUP LIMITED (GB) 2008-01-16 EP disclosed
US-20060293354-A1 Pyrimidine derivatives and their use as CB2 modulators GLAXO GROUP LIMITED (GB) 2006-12-28 US disclosed
EP-1732561-A1 COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE GLAXO GROUP LIMITED (GB) 2006-12-20 EP disclosed
WO-2005074939-A1 COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE GLAXO GROUP LIMITED (GB) 2005-08-18 WO disclosed
EP-1539712-A1 PYRIMIDINE DERIVATIVES AND THEIR USE AS CB2 MODULATORS GLAXO GROUP LIMITED (GB) 2005-06-15 EP disclosed
WO-2004018433-A1 PYRIMIDINE DERIVATIVES AND THEIR USE AS CB2 MODULATORS GLAXO GROUP LIMITED (GB) 2004-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230293479-A1 MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS GPR18, SLC1A5, CNR2 CNR2 3/4885LRRK2 3305/4885CYP1A2 605/4885
US-20250152509-A1 PARTICLES, AQUEOUS DISPERSIONS, AND LIQUID COMPOSITIONS HAVING HIGH LIPOPHILIC COMPONENT CONCENTRATIONS AND HIGH LIPOPHILIC COMPONENT TO SURFACTANT RATIOS NAPEPLD, CNR1, CNR2 CNR2 3/4885LRRK2 1006/4885CYP1A2 1154/4885
US-20250268861-A1 N-ACYLATED FATTY AMINO ACIDS TO REDUCE ABSORPTION VARIABILITY IN CANNABINOID BASED COMPOSITIONS FAAH, CNR2, FABP2 CNR2 2/4885LRRK2 3908/4885CYP1A2 593/4885
US-12303487-B2 N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions FAAH, CNR2, FABP2 CNR2 2/4885LRRK2 3908/4885CYP1A2 593/4885
US-20240009208-A1 STABILIZATION OF CANNABINOIDS WITHIN SOLID DOSAGE FORMS DGKZ, DSP, DMPK CNR2 6/4885LRRK2 820/4885CYP1A2 3370/4885
US-20060293354-A1 Pyrimidine derivatives and their use as CB2 modulators CNR2, CNR1, P2RX3 CNR2 1/4885LRRK2 2759/4885CYP1A2 1273/4885
US-20240261303-A1 PARTICLES, AQUEOUS DISPERSIONS, AND COMPOSITIONS HAVING HIGH LIPOPHILIC COMPONENT CONCENTRATIONS AND HIGH LIPOPHILIC COMPONENT TO SURFACTANT RATIOS LIPA, PLIN3, LPL CNR2 1444/4885LRRK2 3182/4885CYP1A2 1956/4885
US-20080132505-A1 Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine CNR2, CNR1, PDE4A CNR2 1/4885LRRK2 2993/4885CYP1A2 1331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.