Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL338465 | 0.86 | RIPK1 (0.43) | NOTUMMAPTGAAALDH1A1LMNA | |
| SCHEMBL12473041 | 0.83 | NOTUM (0.53) | NOTUMMAPTGAAALDH1A1LMNA | |
| SCHEMBL339093 | 0.82 | TAS1R3 (0.48) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL338418 | 0.80 | MEN1 (0.41) | NOTUMGAAALDH1A1LMNAMMP1 | |
| SCHEMBL337853 | 0.79 | NOTUM (0.42) | NOTUMMAPTGAAALDH1A1LMNA | |
| SCHEMBL338050 | 0.79 | RIPK1 (0.45) | ALDH1A1MMP13NPC1RAB9AMEN1 | |
| SCHEMBL5055669 | 0.78 | MMP1 (0.53) | ALDH1A1MMP1MMP7MMP9MMP8 | |
| SCHEMBL14312482 | 0.77 | NOTUM (0.40) | NOTUMMAPTGAAALDH1A1LMNA | |
| SCHEMBL10055938 | 0.76 | HPGD (0.41) | NOTUMMAPTALDH1A1LMNARAB9A | |
| SCHEMBL338653 | 0.75 | ATM (0.41) | NOTUMALDH1A1LMNAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12083105-B2 | Compositions and methods for treating adult-onset neuronal ceroid lipofuscinosis (Kufs disease) | CORNELL UNIVERSITY (US) | 2024-09-10 | — | — | US | claimed |
| EP-1687298-B1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC (CA) | 2012-12-26 | — | — | EP | claimed |
| US-7410985-B2 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | APOTEX INC. (CA) | 2008-08-12 | — | — | US | claimed |
| EP-1687298-A4 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC (CA) | 2007-10-17 | — | — | EP | claimed |
| US-20070082904-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones field of the invention | APOTEX INC. (CA) | 2007-04-12 | — | — | US | claimed |
| EP-1687298-A1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | Apotex Inc. (CA) | 2006-08-09 | — | — | EP | claimed |
| WO-2005049609-A1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC. (CA) | 2005-06-02 | — | — | WO | claimed |
| US-12083105-B2 | Compositions and methods for treating adult-onset neuronal ceroid lipofuscinosis (Kufs disease) | CORNELL UNIVERSITY (US) | 2024-09-10 | — | — | US | disclosed |
| US-10064858-B2 | Methods and compositions for treating bacterial infections with iron chelators | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2018-09-04 | — | — | US | disclosed |
| EP-2670417-A1 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS WITH IRON CHELATORS | The United States Of America As Represented By The Secretary of the Army (US) | 2013-12-11 | — | — | EP | disclosed |
| US-20130310346-A1 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS WITH IRON CHELATORS | GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2013-11-21 | — | — | US | disclosed |
| US-20130310346-A1 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS WITH IRON CHELATORS | GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2013-11-21 | — | — | US | disclosed |
| EP-1687298-B1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC (CA) | 2012-12-26 | — | — | EP | disclosed |
| EP-1824823-A1 | PROCESS FOR THE MANUFACTURE OF 3-HYDROXY-N-ALKYL-1-CYCLOALKYL-6-ALKYL-4-OXO-1,4-DIHYDROPYRIDINE-2-CARBOXAMIDE AND ITS RELATED ANALOGUES | Apotex Inc. (CA) | 2007-08-29 | — | — | EP | disclosed |
| US-20070082904-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones field of the invention | APOTEX INC. (CA) | 2007-04-12 | — | — | US | disclosed |
| US-20070082904-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones field of the invention | APOTEX INC. (CA) | 2007-04-12 | — | — | US | disclosed |
| US-20070082904-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones field of the invention | APOTEX INC. (CA) | 2007-04-12 | — | — | US | disclosed |
| EP-1687298-A1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | Apotex Inc. (CA) | 2006-08-09 | — | — | EP | disclosed |
| WO-2006053429-A1 | PROCESS FOR THE MANUFACTURE OF 3-HYDROXY-N-ALKYL-1-CYCLOALKYL-6-ALKYL-4-OXO-1,4-DIHYDROPYRIDINE-2-CARBOXAMIDE AND ITS RELATED ANALOGUES | APOTEX INC. (CA) | 2006-05-26 | — | — | WO | disclosed |
| WO-2005049609-A1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC. (CA) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310346-A1 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS WITH IRON CHELATORS | FTH1, TFRC, HAMP | NOTUM 4267/4885MAPT 4001/4885GAA 292/4885 |
| US-12083105-B2 | Compositions and methods for treating adult-onset neuronal ceroid lipofuscinosis (Kufs disease) | CLN6, HNRNPL, HNRNPLL | NOTUM 3029/4885MAPT 1045/4885GAA 52/4885 |
| US-10064858-B2 | Methods and compositions for treating bacterial infections with iron chelators | FTH1, TFRC, HAMP | NOTUM 4267/4885MAPT 4001/4885GAA 292/4885 |
| US-20070082904-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones field of the invention | HAMP, C1S, SLC40A1 | NOTUM 4672/4885MAPT 4510/4885GAA 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.