SCHEMBL338774

SCHEMBL338774

C=C(C)C(=O)C(C[N+](C)(C)C)OP(=O)([O-])O

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
CYP1A2 P05177 1/20 0.36
HRH1 P35367 1/20 0.36
SLC22A16 Q86VW1 1/20 0.34
TSHR P16473 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
CHRM1 P11229 1/20 0.33
TBXA2R P21731 1/20 0.33
CRAT P43155 1/20 0.33
CPT2 P23786 1/20 0.33
CPT1A P50416 1/20 0.33
GALR3 O60755 1/20 0.33
MAPT P10636 1/20 0.33
BLM P54132 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CYP2C19 P33261 1/20 0.31
RECQL P46063 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5157841 0.88 TSHR (0.36) MEN1KMT2ACYP1A2HRH1SLC22A16
SCHEMBL8910736 0.80 LAP3 (0.37) MEN1KMT2ACYP1A2HRH1SLC22A16
SCHEMBL7950629 0.79 MEN1 (0.31) MEN1KMT2ACYP1A2HRH1SMN1; SMN2
SCHEMBL946299 0.78 BTN3A1 (0.30)
SCHEMBL1003887 0.77 SLC22A16 (0.31) SLC22A16TSHRCHRM2CHRM4CHRM1
SCHEMBL7702001 0.74 TSHR (0.38) MEN1KMT2ACYP1A2HRH1SLC22A16
SCHEMBL80350 0.71 THRB (0.36) MEN1KMT2ACYP1A2HRH1TSHR
SCHEMBL14988988 0.70 TSHR (0.37) MEN1KMT2ACYP1A2HRH1TSHR
SCHEMBL6276269 0.70 THRB (0.39) MEN1KMT2ACYP1A2HRH1TSHR
SCHEMBL1260630 0.70 MEN1 (0.33) MEN1KMT2ACYP1A2HRH1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9750847-B2 Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2017-09-05 US disclosed
US-20160038636-A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-02-11 US disclosed
EP-2454286-B1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES MENICON CO LTD (JP) 2015-12-16 EP disclosed
US-9199000-B2 Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2015-12-01 US disclosed
WO-2015065100-A1 SPHERICAL HYDROGEL PARTICLES USING MPC AND WATER-SOLUBLE CROSSLINKING AGENT 주식회사 아모레퍼시픽 2015-05-07 WO disclosed
US-20140193476-A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2014-07-10 US disclosed
US-8709470-B2 Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities MENICON CO., LTD. (JP) 2014-04-29 US disclosed
US-20120164208-A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2012-06-28 US disclosed
EP-2454286-A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES Menicon Co., Ltd. (JP) 2012-05-23 EP disclosed
US-8097253-B2 Methods for inhibiting angiogenesis UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2012-01-17 US disclosed
US-20070166382-A1 Bioresponsive polymer system for delivery of microbicides UNIVERSITY OF UTAH RESEARCH FOUNDATION 2007-07-19 US disclosed
EP-1773375-A1 NETRIN-RELATED COMPOSITIONS AND USES University of Utah Research Foundation (US) 2007-04-18 EP disclosed
EP-1737500-A1 BIORESPONSIVE POLYMER SYSTEM FOR DELIVERY OF MICROBICIDES The University of Utah Research Foundation (US) 2007-01-03 EP disclosed
US-7125837-B1 biodrugs consisting of proteins having amino acid sequences attached to biocompatible supports or dissolved in matrices having antiproliferative, cell differentiation stimulation, controlling migration and binding of smooth muscle, used for prophylaxis of restenosis UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2006-10-24 US disclosed
WO-2006019904-A1 NETRIN-RELATED COMPOSITIONS AND USES UNIVERSITY OF UTHA RESEARCH FOUNDATION (US) 2006-02-23 WO disclosed
US-20060019896-A1 Netrin-related compositions and uses UNIVERSITY OF UTAH RESEARCH FOUNDATION 2006-01-26 US disclosed
US-20050261189-A1 Methods of promoting cardiac cell proliferation HYDRA BIOSCIENCES, INC. 2005-11-24 US disclosed
WO-2005097210-A1 BIORESPONSIVE POLYMER SYSTEM FOR DELIVERY OF MICROBICIDES THE UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2005-10-20 WO disclosed
EP-1175225-A2 ELASTIN-BASED COMPOSITIONS The University of Utah Research Foundation (US) 2002-01-30 EP disclosed
WO-2000050068-A2 ELASTIN-BASED COMPOSITIONS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2000-08-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160038636-A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES ACMSD, CDC37, USP30 MEN1 3189/4885KMT2A 2712/4885CYP1A2 2607/4885
US-20050261189-A1 Methods of promoting cardiac cell proliferation MKI67, TNNI3, TNNT2 MEN1 4264/4885KMT2A 2828/4885CYP1A2 4737/4885
US-20140193476-A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES ACMSD, CDC37, USP30 MEN1 3189/4885KMT2A 2712/4885CYP1A2 2607/4885
US-20120164208-A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES CRYZ, CRYAA, USP30 MEN1 3263/4885KMT2A 3282/4885CYP1A2 2176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.