Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7631802 | 0.95 | HIF1A (0.35) | HIF1ASLC18A2CYP1A2CYP2D6GAA | |
| Bromide SCHEMBL2447458 | 0.95 | GAA (0.36) | HIF1ACYP2D6GAAL3MBTL1IDO1 | |
| Iodide SCHEMBL7626801 | 0.95 | HIF1A (0.35) | HIF1ASLC18A2CYP1A2CYP2D6GAA | |
| Bromide SCHEMBL7633092 | 0.93 | IDO1 (0.38) | HIF1AGAAL3MBTL1IDO1 | |
| Bromide SCHEMBL2445980 | 0.93 | IDO1 (0.38) | HIF1AGAAL3MBTL1IDO1 | |
| Bromide SCHEMBL3322091 | 0.93 | IDO1 (0.38) | HIF1AGAAL3MBTL1IDO1 | |
| SCHEMBL31321441 | 0.92 | GAA (0.38) | HIF1ACYP2D6GAAL3MBTL1IDO1 | |
| Bromide SCHEMBL1082615 | 0.92 | HIF1A (0.36) | HIF1AIDO1 | |
| Bromide SCHEMBL10533526 | 0.91 | IDO1 (0.37) | HIF1ACYP1A2GAAL3MBTL1IDO1 | |
| Iodide SCHEMBL6591776 | 0.90 | GAA (0.36) | HIF1ACYP2D6GAAL3MBTL1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481828-B2 | Liquid Crystal compound containing cyclobutyl group and difluoromethyleneoxy linking group, and preparation method and use thereof | SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIAL CO., LTD. (CN) | 2016-11-01 | — | — | US | disclosed |
| US-20150284632-A1 | Liquid Crystal Compound Containing Cyclobutyl Group and Difluoromethyleneoxy Linking Group, and Preparation Method and Use Thereof | SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO., LTD. (CN) | 2015-10-08 | — | — | US | disclosed |
| US-8455466-B2 | Vitamin d analogues, compositions comprising said analogues and their use | LEO PHARMA A/S (DK) | 2013-06-04 | — | — | US | disclosed |
| EP-1556345-B1 | VITAMIN D ANALOGUES, COMPOSITIONS COMPRISING SAID ANALOGUES AND THEIR USE | LEO PHARMA AS (DK) | 2010-12-15 | — | — | EP | disclosed |
| US-20060166949-A1 | Vitamin d analogues, compositions comprising said analogues and their use | LEO PHARMA A/S (DE) | 2006-07-27 | — | — | US | disclosed |
| CN-1705643-A | Vitamin D analogues, compositions comprising said analogues and their use | LEO PHARMA AS (DK) | 2005-12-07 | — | — | CN | disclosed |
| EP-1556345-A1 | VITAMIN D ANALOGUES, COMPOSITIONS COMPRISING SAID ANALOGUES AND THEIR USE | Leo Pharma A/S (DK) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004037781-A1 | VITAMIN D ANALOGUES, COMPOSITIONS COMPRISING SAID ANALOGUES AND THEIR USE | LEO PHARMA A/S (DK) | 2004-05-06 | — | — | WO | disclosed |
| EP-0780452-B1 | Aqueous paint | TOYO SEIKAN KAISHA LTD (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-5763507-A | EPOXY ACRYLATE RESIN | TOYO SEIKAN KAISHA, LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0780452-A2 | Aqueous paint | TOYO SEIKAN KAISHA LIMITED (JP) | 1997-06-25 | — | — | EP | disclosed |
| US-5310854-A | Solvent, coatings for beverage cans | THE DOW CHEMICAL COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| EP-0329021-B1 | Preparation of advanced epoxy resins and dihydric phenols in the presence of phosphonium compounds | DOW CHEMICAL CO (US) | 1994-01-26 | — | — | EP | disclosed |
| US-5206312-A | Polysiloxanes hydrosilated with unsaturated aromatic alcohols and siloxy-containing compounds having hydroxy groups to advance polyepoxides and epoxy resins; electronics; coatings; composites | THE DOW CHEMICAL COMPANY (US) | 1993-04-27 | — | — | US | disclosed |
| WO-1991016888-A1 | SPIRO[BENZOFURANCYCLOALKANE]CARBOXAMIDES AS 5HT3 ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-11-14 | — | — | WO | disclosed |
| EP-0329021-A2 | Preparation of advanced epoxy resins and dihydric phenols in the presence of phosphonium compounds | THE DOW CHEMICAL COMPANY (US) | 1989-08-23 | — | — | EP | disclosed |
| US-4808692-A | Preparation of advanced epoxy resins from epoxy resins and dihydric phenols in the presence of phosphonium compounds | THE DOW CHEMICAL COMPANY (US) | 1989-02-28 | — | — | US | disclosed |
| US-4206140-A | INSECTICIDES, ANTHELMINTICS | ROUSSEL UCLAF (FR) | 1980-06-03 | — | — | US | disclosed |
| US-4101574-A | Cyclopropanecarboxylic acid chlorides | ROUSSEL UCLAF (FR) | 1978-07-18 | — | — | US | disclosed |
| US-3997586-A | Cyclopropanecarboxylic acids and esters | ROUSSEL-UCLAF (FR) | 1976-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284632-A1 | Liquid Crystal Compound Containing Cyclobutyl Group and Difluoromethyleneoxy Linking Group, and Preparation Method and Use Thereof | CFB, CFL1, FASTKD1 | HIF1A 4619/4885SLC18A2 4136/4885CYP1A2 1641/4885 |
| US-20060166949-A1 | Vitamin d analogues, compositions comprising said analogues and their use | VDR, CYP2R1, CYP24A1 | HIF1A 1273/4885SLC18A2 3621/4885CYP1A2 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.