SCHEMBL3404909

SCHEMBL3404909

COc1ccc(N2C(=O)c3ccc4c5ccc6c7c(ccc(c8ccc(c3c48)C2=O)c75)C(=O)N(c2ccc(OC)cc2)C6=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.59
NR1H3 Q13133 2/20 0.55
KMT2A Q03164 6/20 0.53
MEN1 O00255 5/20 0.52
POLB P06746 2/20 0.51
APAF1 O14727 1/20 0.51
MGLL Q99685 1/20 0.51
ALDH1A1 P00352 2/20 0.49
PGR P06401 1/20 0.48
MAPT P10636 1/20 0.48
MAPK1 P28482 1/20 0.48
HSD17B10 Q99714 1/20 0.48
KDM4E B2RXH2 1/20 0.47
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29355675 1.00 ESR1 (0.59) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL30720985 1.00 ESR1 (0.59) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL15672159 0.94 ESR1 (0.57) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL5578422 0.94 ESR1 (0.54) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL12639210 0.93 ESR1 (0.66) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL7647376 0.90 KMT2A (0.58) ESR1NR1H3KMT2AMEN1ALDH1A1
SCHEMBL12577485 0.89 NR1H3 (0.56) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL12341700 0.87 ESR1 (0.63) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL14124834 0.87 ESR1 (0.48) ESR1NR1H3KMT2AMEN1POLB
SCHEMBL14125027 0.87 ESR1 (0.48) ESR1NR1H3KMT2AMEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230310300-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER HFC PRESTIGE SERVICE GERMINY GMBH (DE) 2023-10-05 US disclosed
EP-4171500-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER Wella Germany GmbH (DE) 2023-05-03 EP disclosed
US-11360386-B2 Organic EL display device TORAY INDUSTRIES, INC. (JP) 2022-06-14 US disclosed
US-11324688-B2 Bicomponent composition WELLA INTERNATIONAL OPERATIONS SWI (CH) 2022-05-10 US disclosed
US-20220054392-A1 MULTICOMPONENT IN SITU COLORATION COMPOSITION WELLA INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2022-02-24 US disclosed
US-20220016017-A1 COLOR COATINGS WITH DOWNSTREAM FEATURES HFC PRESTIGE SERVICE GERMANY GMBH (DE) 2022-01-20 US disclosed
WO-2022002983-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER HFC PRESTIGE SERVICE GERMANY GMBH (DE) 2022-01-06 WO disclosed
EP-3890683-A1 MULTICOMPONENT IN SITU COLORATION COMPOSITION HFC Prestige International Holding Switzerland S.a.r.l. (CH) 2021-10-13 EP disclosed
US-20210290518-A1 MULTICOMPONENT COMPOSITION HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) 2021-09-23 US disclosed
US-20210290519-A1 MULTICOMPONENT SILICONE COMPOSITION WELLA INT OPERATIONS SWITZERLAND SARL (CH) 2021-09-23 US disclosed
US-20100330496-A1 SIMULTANEOUS TWO-PHOTON ABSORPTION RECORDING-REPRODUCTION METHOD, AND SIMULTANEOUS TWO-PHOTON ABSORPTION RECORDING MATERIAL FOR USE THEREIN FUJIFILM CORPORATION (JP) 2010-12-30 US disclosed
US-20100330496-A1 SIMULTANEOUS TWO-PHOTON ABSORPTION RECORDING-REPRODUCTION METHOD, AND SIMULTANEOUS TWO-PHOTON ABSORPTION RECORDING MATERIAL FOR USE THEREIN FUJIFILM CORPORATION (JP) 2010-12-30 US disclosed
US-20100152339-A1 Graft Copolymer And Compositions Thereof LUBRIZOL LIMITED (GB) 2010-06-17 US disclosed
EP-2150333-A1 GRAFT COPOLYMER AND COMPOSITIONS THEREOF Lubrizol Limited (GB) 2010-02-10 EP disclosed
WO-2009144115-A1 IMPROVED, RED COLOUR FILTER COMPOSITION BASF SE (DE) 2009-12-03 WO disclosed
WO-2008145613-A1 GRAFT COPOLYMER AND COMPOSITIONS THEREOF LUBRIZOL LIMITED (GB) 2008-12-04 WO disclosed
EP-1541726-B1 POLYBENZAZOLE FIBER AND USE THEREOF TOYO BOSEKI (JP) 2008-10-01 EP disclosed
US-7357982-B2 For cords for reinforcing rubber, sheets and rods for reinforcing cement/concrete, composite materials, sail clothes, ropes, knife proof vests and bullet proof vests; staple fibers, spun yarns, and woven or knitted fabrics; heat resistance as high as a thermal decomposition temperature TOYO BOSEKI KABUSHIKI KAISHA (JP) 2008-04-15 US disclosed
US-20060083923-A1 For cords for reinforcing rubber, sheets and rods for reinforcing cement/concrete, composite materials, sail clothes, ropes, knife proof vests and bullet proof vests; staple fibers, spun yarns, and woven or knitted fabrics; heat resistance as high as a thermal decomposition temperature TOYO BOSEKI KABUSHIKI KAISHA (JP) 2006-04-20 US disclosed
EP-1541726-A1 POLYBENZAZOLE FIBER AND USE THEREOF Toyo Boseki Kabushiki Kaisha (JP) 2005-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220016017-A1 COLOR COATINGS WITH DOWNSTREAM FEATURES KRT18, ITGA5, FLNA ESR1 1722/4885NR1H3 1214/4885KMT2A 586/4885
US-20230310300-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER KRT18, MKI67, IK ESR1 3740/4885NR1H3 4808/4885KMT2A 876/4885
US-20210290519-A1 MULTICOMPONENT SILICONE COMPOSITION CUTA, CD99, PLOD3 ESR1 2740/4885NR1H3 3246/4885KMT2A 648/4885
US-20220054392-A1 MULTICOMPONENT IN SITU COLORATION COMPOSITION KRT18, PRKDC, VIM ESR1 4432/4885NR1H3 4139/4885KMT2A 1653/4885
US-11324688-B2 Bicomponent composition KRT18, EXOSC10, EXOSC9 ESR1 4314/4885NR1H3 4742/4885KMT2A 1253/4885
US-20210290518-A1 MULTICOMPONENT COMPOSITION KRT18, INCENP, IK ESR1 4499/4885NR1H3 4295/4885KMT2A 684/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.