Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 15/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202322 | 0.80 | OPRL1 (0.70) | OPRL1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL517855 | 0.79 | OPRL1 (0.68) | OPRL1OPRM1OPRK1 | |
| SCHEMBL1721462 | 0.78 | ALDH1A1 (0.48) | OPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL3407459 | 0.78 | VNN1 (0.40) | OPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL3406898 | 0.76 | OPRL1 (0.50) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3410234 | 0.75 | OPRL1 (0.49) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3410998 | 0.75 | HSD11B1 (0.39) | OPRM1ALDH1A1 | |
| SCHEMBL17443954 | 0.74 | SLC6A4 (0.33) | OPRL1OPRM1 | |
| SCHEMBL3924344 | 0.74 | OPRM1 (0.46) | OPRL1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL4254876 | 0.73 | OPRL1 (0.44) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257527-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-08 | — | — | EP | disclosed |
| US-20090253669-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253669-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253669-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| WO-2009115257-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253669-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | OPRL1 2189/4885OPRM1 2798/4885OPRK1 2548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.