SCHEMBL1364657

SCHEMBL1364657

NNC(=O)c1ccc(-n2cccn2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC2 O75106 1/20 0.58
KDM4E B2RXH2 4/20 0.50
DGAT1 O75907 2/20 0.50
ALDH1A1 P00352 2/20 0.50
MAPK1 P28482 1/20 0.50
TP53 P04637 1/20 0.50
NOTUM Q6P988 1/20 0.50
MPO P05164 2/20 0.49
CYP3A4 P08684 2/20 0.49
CYP1A2 P05177 1/20 0.49
ADORA3 P0DMS8 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2A6 P11509 1/20 0.49
CYP2C19 P33261 1/20 0.49
MAPT P10636 2/20 0.48
LMNA P02545 2/20 0.48
HDAC4 P56524 1/20 0.47
SIRT2 Q8IXJ6 1/20 0.47
SIRT1 Q96EB6 1/20 0.47
SIRT3 Q9NTG7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL323044 0.81 NOTUM (0.55) KDM4EALDH1A1MAPK1TP53NOTUM
SCHEMBL17303476 0.81 NOTUM (0.58) KDM4EDGAT1ALDH1A1MAPK1TP53
SCHEMBL23459990 0.81 GCGR (0.60) KDM4EDGAT1TP53MAPTRXFP1
SCHEMBL4253031 0.80 RAB9A (0.62) KDM4EDGAT1ALDH1A1TP53MAPT
SCHEMBL321724 0.80 LMNA (0.61) KDM4EDGAT1ALDH1A1MAPK1TP53
SCHEMBL8770154 0.79 MEN1 (0.55) KDM4EALDH1A1TP53MAPTLMNA
SCHEMBL8769758 0.79 ALDH1A1 (0.55) KDM4EALDH1A1TP53MAPTLMNA
SCHEMBL16595887 0.79 NOTUM (0.51) KDM4EALDH1A1MAPK1TP53NOTUM
SCHEMBL1019716 0.78 NOTUM (0.59) KDM4EALDH1A1MAPK1TP53NOTUM
SCHEMBL609355 0.78 TP53 (0.68) KDM4EALDH1A1MAPK1TP53NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 US disclosed
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 US disclosed
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors ENANTA PHARM INC (US) 2024-10-31 US disclosed
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-04-09 US disclosed
EP-3687543-B1 COMBINATIONS OF PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARM INC (US) 2024-03-20 EP disclosed
CN-111386118-B Combination pharmaceutical agents as RSV inhibitors 英安塔制药有限公司 2023-05-09 CN disclosed
US-20230087410-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2023-03-23 US disclosed
US-20220323460-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARM INC (US) 2022-10-13 US disclosed
US-11390631-B1 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2022-07-19 US disclosed
EP-3324977-B1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2022-07-13 EP disclosed
US-20110224267-A1 Selective androgen receptor modulators Radius Health,Inc. (US) 2011-09-15 US disclosed
EP-2260028-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS Radius Health, Inc. (US) 2010-12-15 EP disclosed
US-20100041721-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2010-02-18 US disclosed
US-20100041721-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2010-02-18 US disclosed
US-20100041721-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2010-02-18 US disclosed
US-20090253758-A1 Selective androgen receptor modulators ELLIPSES PHARMA LTD (GB) 2009-10-08 US disclosed
US-20090253758-A1 Selective androgen receptor modulators ELLIPSES PHARMA LTD (GB) 2009-10-08 US disclosed
US-20090253758-A1 Selective androgen receptor modulators ELLIPSES PHARMA LTD (GB) 2009-10-08 US disclosed
WO-2009105214-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2009-08-27 WO disclosed
WO-2009105214-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2009-08-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041721-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS AR, SHBG, IGF1R AOC2 3741/4885KDM4E 1712/4885DGAT1 3614/4885
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors GABRA5, GABRA1, GABBR2 AOC2 4556/4885KDM4E 1198/4885DGAT1 4535/4885
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 AOC2 4556/4885KDM4E 1198/4885DGAT1 4535/4885
US-20110224267-A1 Selective androgen receptor modulators AR, SHBG, GPR119 AOC2 3751/4885KDM4E 1482/4885DGAT1 3908/4885
US-11390631-B1 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 AOC2 4556/4885KDM4E 1198/4885DGAT1 4535/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 AOC2 4556/4885KDM4E 1198/4885DGAT1 4535/4885
US-20220323460-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS SERPINB1, FURIN, HIF1AN AOC2 4660/4885KDM4E 3876/4885DGAT1 4344/4885
US-20230087410-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 AOC2 4556/4885KDM4E 1198/4885DGAT1 4535/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 AOC2 4792/4885KDM4E 4059/4885DGAT1 4319/4885
US-20090253758-A1 Selective androgen receptor modulators AR, SHBG, GPR119 AOC2 3751/4885KDM4E 1482/4885DGAT1 3908/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.