Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6327779 | 0.79 | NOTUM (0.48) | NOTUM | |
| SCHEMBL10264319 | 0.77 | GABRA1 (0.44) | NPSR1KEAP1 | |
| SCHEMBL5368133 | 0.76 | KEAP1 (0.42) | NPSR1KEAP1FFAR1FFAR4 | |
| SCHEMBL1004268 | 0.75 | ALDH1A1 (0.50) | KEAP1FFAR1FFAR4 | |
| SCHEMBL5670212 | 0.73 | KEAP1 (0.64) | NPSR1KEAP1FFAR1FFAR4RXRA | |
| SCHEMBL5846204 | 0.72 | FFAR1 (0.61) | NPSR1KEAP1FFAR1FFAR4RXRA | |
| SCHEMBL13103035 | 0.72 | ALDH1A1 (0.45) | FFAR1FFAR4PPARG | |
| SCHEMBL20206944 | 0.72 | — | — | |
| SCHEMBL18258239 | 0.71 | NPSR1 (0.57) | NPSR1KEAP1FFAR1FFAR4 | |
| SCHEMBL25240683 | 0.71 | DAO (0.47) | NPSR1KEAP1FFAR1FFAR4RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140186875-A1 | NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSIS | MONTANA STATE UNIVERSITY (US) | 2014-07-03 | — | — | US | disclosed |
| US-20100252433-A1 | NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSES | NATIONAL SCIENCE FOUNDATION | 2010-10-07 | — | — | US | disclosed |
| US-20100252433-A1 | NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSES | NATIONAL SCIENCE FOUNDATION | 2010-10-07 | — | — | US | disclosed |
| US-20100252433-A1 | NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSES | NATIONAL SCIENCE FOUNDATION | 2010-10-07 | — | — | US | disclosed |
| EP-2164997-A2 | NOVEL OPTICAL LABELING MOLECULES IN PROTEOMICS AND OTHER BIOLOGICAL ANALYSES | Montana State University (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009005871-A2 | NOVEL OPTICAL LABELING MOLECULES IN PROTEOMICS AND OTHER BIOLOGICAL ANALYSES | MONTANA STATE UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005871-A2 | NOVEL OPTICAL LABELING MOLECULES IN PROTEOMICS AND OTHER BIOLOGICAL ANALYSES | MONTANA STATE UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |
| US-20060166982-A1 | Isotopically labelly indlinone derivatives and process for their preparation | PFIZER ITALIA S.R.L. (IT) | 2006-07-27 | — | — | US | disclosed |
| EP-1542734-A1 | ISOTOPICALLY LABELLED INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Pharmacia Italia S.p.A. (IT) | 2005-06-22 | — | — | EP | disclosed |
| US-6855730-B2 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| WO-2004012776-A1 | ISOTOPICALLY LABELLED INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA S.P.A. (IT) | 2004-02-12 | — | — | WO | disclosed |
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. | 2004-02-05 | — | — | US | disclosed |
| US-6531502-B1 | Antitumor | SUGEN, INC. | 2003-03-11 | — | — | US | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100252433-A1 | NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSES | PTMS, CHAMP1, RAB5IF | NPSR1 3986/4885KEAP1 2755/4885NOTUM 485/4885 |
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | DMPK, MAP4K3, MAP3K20 | NPSR1 3588/4885KEAP1 1622/4885NOTUM 3157/4885 |
| US-20060166982-A1 | Isotopically labelly indlinone derivatives and process for their preparation | CYP3A5, SLC10A2, TMEM14C | NPSR1 2446/4885KEAP1 2386/4885NOTUM 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.