Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3420578 | 0.85 | LMNA (0.53) | LMNAMAPTPOLBPKMELANE | |
| SCHEMBL7765430 | 0.82 | ELANE (0.51) | LMNAMAPTPOLBPKMELANE | |
| SCHEMBL2887218 | 0.81 | PTGS2 (0.59) | LMNAMAPTHSD17B10ALDH1A1MEN1 | |
| SCHEMBL11779417 | 0.80 | RAB9A (0.66) | LMNAMAPTPKMHSD17B10GAA | |
| SCHEMBL269329 | 0.78 | LMNA (0.80) | LMNAMAPTPOLBPKMELANE | |
| SCHEMBL20183978 | 0.78 | THRB (0.47) | MAPTELANEHSD17B10ALDH1A1P2RY6 | |
| SCHEMBL10208135 | 0.78 | LMNA (0.59) | LMNAMAPTPOLBPKMELANE | |
| Methacrylic Acid SCHEMBL31274994 | 0.76 | HSD17B10 (0.39) | ELANEHSD17B10P2RY6MIFCA1 | |
| SCHEMBL14760365 | 0.76 | LMNA (0.76) | LMNAMAPTPOLBPKMELANE | |
| Lithium SCHEMBL30522746 | 0.76 | LMNA (0.76) | LMNAMAPTPOLBPKMELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662977-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080188423-A1 | PI-3 KINASE INHIBITOR PRODRUGS | SIGNALRX PHARMACEUTICALS, INC. | 2008-08-07 | — | — | US | disclosed |
| US-7396828-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1611119-A1 | PI-3 KINASE INHIBITOR PRODRUGS | Semafore Pharmaceuticals, Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| US-6949537-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2005-09-27 | — | — | US | disclosed |
| US-20050203173-A1 | PI-3 kinase inhibitor prodrugs | SIGNALRX PHARMACEUTICALS, INC. | 2005-09-15 | — | — | US | disclosed |
| US-20040242631-A1 | PI-3 kinase inhibitor prodrugs | SIGNALRX PHARMACEUTICALS, INC. | 2004-12-02 | — | — | US | disclosed |
| WO-2004089925-A1 | PI-3 KINASE INHIBITOR PRODRUGS | SEMAFORE PHARMACEUTICALS, INC. (US) | 2004-10-21 | — | — | WO | disclosed |
| US-4399286-A | Antiarrhythmic phenethylpiperidine compounds | MEAD JOHNSON & COMPANY (US) | 1983-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203173-A1 | PI-3 kinase inhibitor prodrugs | PI4KA, PI4KB, PI4K2B | LMNA 3669/4885MAPT 3144/4885POLB 2276/4885 |
| US-20080188423-A1 | PI-3 KINASE INHIBITOR PRODRUGS | PI4KA, PI4KB, PI4K2B | LMNA 3669/4885MAPT 3144/4885POLB 2276/4885 |
| US-20040242631-A1 | PI-3 kinase inhibitor prodrugs | PI4KA, PI4KB, PI4K2B | LMNA 3669/4885MAPT 3144/4885POLB 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.