Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5637165 | 1.00 | DRD2 (0.38) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL3421132 | 1.00 | DRD2 (0.38) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL9405511 | 0.86 | DRD2 (0.38) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL9405512 | 0.86 | DRD2 (0.38) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL30899722 | 0.83 | OPRK1 (0.42) | CCR2KCNH2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8481404 | 0.83 | OPRK1 (0.42) | CCR2KCNH2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3420326 | 0.83 | SLC6A3 (0.39) | KCNH2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3422690 | 0.83 | SLC6A3 (0.39) | KCNH2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3420294 | 0.83 | SLC6A3 (0.39) | KCNH2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL5971900 | 0.80 | CCR2 (0.39) | DRD2DRD4SLC18A3SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105678-B2 | Boat tropanes | ORGANIX, INC. (US) | 2006-09-12 | — | — | US | claimed |
| EP-1518562-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-03-30 | — | — | EP | claimed |
| EP-1518561-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-03-30 | — | — | EP | claimed |
| US-20020131931-A1 | Boat tropanes | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2002-09-19 | — | — | US | claimed |
| EP-1051980-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-11-15 | — | — | EP | claimed |
| EP-1051980-B1 | Dopamine transporter imaging agents | HARVARD COLLEGE (US) | 2010-12-15 | — | — | EP | disclosed |
| US-20090208415-A1 | Tropane compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-08-20 | — | — | US | disclosed |
| US-7476740-B2 | Monoamine transporter inhibitors; used for early diagnosis and treatment of neurological and psychiatric conditions | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-01-13 | — | — | US | disclosed |
| US-20070009432-A1 | Boat tropanes | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-01-11 | — | — | US | disclosed |
| US-7105678-B2 | Boat tropanes | ORGANIX, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| EP-1518562-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1518561-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-03-30 | — | — | EP | disclosed |
| US-20030232819-A1 | Tropane compounds | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2003-12-18 | — | — | US | disclosed |
| US-6548041-B1 | Diagnosis, therapy of central nervous system disorders | ORGANIX, INC. | 2003-04-15 | — | — | US | disclosed |
| US-20020131931-A1 | Boat tropanes | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2002-09-19 | — | — | US | disclosed |
| EP-1238978-A2 | Intermediates for the synthesis of radiolabelled tropanes | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1051980-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020131931-A1 | Boat tropanes | SLC6A3, SLC18A2, SLC6A4 | DRD2 10/4885DRD4 50/4885SLC18A3 5/4885 |
| US-20030232819-A1 | Tropane compounds | TPM3, TPM4, ADRA2C | DRD2 664/4885DRD4 507/4885SLC18A3 56/4885 |
| US-20090208415-A1 | Tropane compounds | TPM3, TPM4, ADRA2C | DRD2 664/4885DRD4 507/4885SLC18A3 56/4885 |
| US-20070009432-A1 | Boat tropanes | SLC6A3, SLC18A2, SLC6A4 | DRD2 10/4885DRD4 50/4885SLC18A3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.